{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:33:59Z","timestamp":1777491239813,"version":"3.51.4"},"reference-count":10,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Paroxysmal localized hyperhidrosis is a rare disorder of the central autonomic nervous system. No association between paroxysmal hyperhidrosis and severe headache has been previously described in literature. Case description: A 65-year-old woman with idiopathic paroxysmal localized hyperhidrosis combined with severe holocranial headache attacks is described in this case report. Extensive diagnostic testing by means of laboratory examinations, 24-hour urinalyses, chest X-ray, abdominal ultrasound and computed tomography scans, and brain and spinal cord magnetic resonance imaging could not identify an underlying disorder. A diagnosis of idiopathic paroxysmal localized hyperhidrosis was made, and the patient was successfully treated with clonidine 0.075\u2009mg three times a day, without any side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Paroxysmal localized hyperhidrosis is a rare central autonomic nervous system disorder that can occur in combination with severe headache. Both the headache and paroxysmal hyperhidrosis complaints were treated effectively with clonidine in the patient described in this case-report.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211006843","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T01:13:09Z","timestamp":1620004389000},"page":"1124-1127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Paroxysmal localized Hyperhidrosis, a case-report: When excessive sweating occurs in combination with severe headaches"],"prefix":"10.1177","volume":"41","author":[{"given":"Marleen H","family":"van Coevorden","sequence":"first","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00ebtte WCJ","family":"Schoofs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Venhovens","sequence":"additional","affiliation":[{"name":"Department of Neurology and Clinical Neurophysiology, Albert Schweitzer Hospital, Dordrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"bibr1-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.12.071"},{"key":"bibr2-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.006"},{"key":"bibr3-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.004"},{"key":"bibr4-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.013"},{"key":"bibr5-03331024211006843","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831020-00002"},{"key":"bibr6-03331024211006843","first-page":"729","volume":"97","author":"McConaghy JR","year":"2018","journal-title":"Am Fam Phys"},{"key":"bibr7-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-017-0456-0"},{"key":"bibr8-03331024211006843","first-page":"706","volume":"142","author":"Namer IJ","year":"1986","journal-title":"Rev Neurol (Paris)"},{"key":"bibr9-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050220112028"},{"key":"bibr10-03331024211006843","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419867280"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211006843","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024211006843","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211006843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:03Z","timestamp":1777387743000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024211006843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,2]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1177\/03331024211006843"],"URL":"https:\/\/doi.org\/10.1177\/03331024211006843","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,2]]}}}