{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:34:16Z","timestamp":1777491256695,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In this paper, we studied several serum clinical chemistry tests of cardiovascular disease (CVD), iron deficiency anemia, liver and kidney disorders in migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We first explored the association of 22 clinical chemistry tests with migraine risk in 697 migraine patients and 2722 controls. To validate and interpret association findings, cross-trait genetic analyses were conducted utilising genome-wide association study (GWAS) data comprising 23,986 to 452,264 individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant associations with migraine risk were identified for biomarkers of CVD risk, iron deficiency and liver dysfunction (odds ratios\u2009=\u20090.86\u20131.21; 1\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      \u2009&lt;\u2009 p\u2009&lt;\u20093\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      ). Results from cross-trait genetic analyses corroborate the significant biomarker associations and indicate their relationship with migraine is more consistent with biological pleiotropy than causality. For example, association and genetic overlap between a lower level of HDL-C and increased migraine risk are due to shared biology rather than a causal relationship. Furthermore, additional genetic analyses revealed shared genetics among migraine, the clinical chemistry tests, and heart problems and iron deficiency anemia, but not liver disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight common biological mechanisms underlying migraine, heart problems and iron deficiency anemia and provide support for their investigation in the development of novel therapeutic and dietary interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211018131","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T01:28:27Z","timestamp":1623806907000},"page":"1208-1221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Association and genetic overlap between clinical chemistry tests and migraine"],"prefix":"10.1177","volume":"41","author":[{"given":"Hamzeh M","family":"Tanha","sequence":"first","affiliation":[{"name":"Queensland University of Technology, Faculty of Health, School of Biomedical Sciences, Centre for Genomics and Personalised Health, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas G","family":"Martin","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B","family":"Whitfield","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale R","family":"Nyholt","sequence":"additional","affiliation":[{"name":"Queensland University of Technology, Faculty of Health, School of Biomedical Sciences, Centre for Genomics and Personalised Health, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The International Headache Genetics Consortium (IHGC)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"bibr1-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/srep26947"},{"key":"bibr2-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.7172"},{"key":"bibr3-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415598757"},{"key":"bibr4-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417699181"},{"key":"bibr5-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2016.43"},{"key":"bibr6-03331024211018131","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2003.00824.x","volume":"24","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr7-03331024211018131","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05910809"},{"key":"bibr8-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3598"},{"key":"bibr9-03331024211018131","unstructured":"UK Biobank GWAS round 2 results (2018). Available at: http:\/\/www.nealelab.is\/uk-biobank\/ (accessed 15 July 2020)."},{"key":"bibr10-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5926"},{"key":"bibr11-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0248-z"},{"key":"bibr12-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1086\/383251"},{"key":"bibr13-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"bibr14-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"bibr15-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu171"},{"key":"bibr16-03331024211018131","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408"},{"key":"bibr17-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0255-0"},{"key":"bibr18-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"bibr19-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000151857.43225.49"},{"key":"bibr20-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411421682"},{"key":"bibr21-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417699181"},{"key":"bibr22-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1186\/s41100-016-0069-4"},{"key":"bibr23-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007313"},{"key":"bibr24-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.28"},{"key":"bibr25-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007047"},{"key":"bibr26-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01467.x"},{"key":"bibr27-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2014-0011"},{"key":"bibr28-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1159\/000452104"},{"key":"bibr29-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-015-0740-8"},{"key":"bibr30-03331024211018131","doi-asserted-by":"crossref","unstructured":"Tayyebi A, Poursadeghfard M, Nazeri M, et al. Is there any correlation between migraine attacks and iron deficiency anemia? A Case-Control Study.\n                      Int J Hematol Oncol Stem Cell Res\n                      2019; 13: 164\u2013171.","DOI":"10.18502\/ijhoscr.v13i3.1276"},{"key":"bibr31-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.04.035"},{"key":"bibr32-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-12-16"},{"key":"bibr33-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.560649"},{"key":"bibr34-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24917-8"},{"key":"bibr35-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01904.x"},{"key":"bibr36-03331024211018131","doi-asserted-by":"crossref","unstructured":"Ndrepepa G and Kastrati A. Gamma-glutamyl transferase and cardiovascular disease.\n                      Ann Transl Med\n                      2016; 4: 481.","DOI":"10.21037\/atm.2016.12.27"},{"key":"bibr37-03331024211018131","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0137-z"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211018131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024211018131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211018131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:06Z","timestamp":1777387746000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024211018131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":37,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1177\/03331024211018131"],"URL":"https:\/\/doi.org\/10.1177\/03331024211018131","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,15]]}}}