{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:32:49Z","timestamp":1787311969186,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to investigate pregnancy and perinatal outcomes in women with tension-type headache, migraine without aura and migraine with aura by comparing them to women without any headache disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Prospective cohort study including singleton pregnancies attending the first trimester aneuploidy screening at the University Hospital of Modena, in Northern Italy, between June 2018 and December 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 515 consecutive women were included and headache disorders were reported in 43.5% of them (224\/515). Tension-type headache was diagnosed in 24.3% of the cases, while 14% suffered from migraine without aura and 5.2% from migraine with aura. Birthweight was significantly lower in women affected by migraine with aura respective to other groups, and a significantly higher rate of small for gestational age infants was found in tension-type headache (10.4%) and in migraine with aura (24.9%) groups respective to the others (p\u2009&lt;\u20090.001). Moreover, the admission to the neonatal intensive care unit was significantly higher in all the headache groups (p\u2009=\u20090.012). Multivariate analysis showed that women presenting tension-type headache (OR 4.19, p\u2009=\u20090.004), migraine with aura (OR 5.37, p\u2009=\u20090.02), a uterine artery pulsatility index &gt;90th centile (OR 3.66, p\u2009=\u20090.01), low multiple of the median (MoM) of Pregnancy-associated plasma protein-A (PAPP-A) (OR 0.48, p\u2009=\u20090.05) and high MoM of Inhibin-A (OR 3.24, p\u2009=\u20090.03) at first trimester, are independently associated with the delivery of small for gestational age infants when compared to women without headache disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Migraine with aura and tension type headache expose women to an increased risk of delivering small for gestational age infants, in association with some utero-placenta markers evaluated at first trimester. These women with headache disorders have an additional indication to undergo first trimester aneuploidy screening and would possibly benefit from specific interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211029236","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T07:04:28Z","timestamp":1626764668000},"page":"1492-1498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Perinatal outcomes in women affected by different types of headache disorders: A prospective cohort study"],"prefix":"10.1177","volume":"41","author":[{"given":"Isabella","family":"Neri","sequence":"first","affiliation":[{"name":"Gynecology & Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-7124","authenticated-orcid":false,"given":"Daniela","family":"Menichini","sequence":"additional","affiliation":[{"name":"International Doctorate School in Clinical and Experimental Medicine, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Monari","sequence":"additional","affiliation":[{"name":"Gynecology & Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica Span\u00f2","family":"Bascio","sequence":"additional","affiliation":[{"name":"Gynecology & Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Banchelli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine, Statistics Unit, University of Modena and Reggio Emilia, University of Modena and Reggio Emilia, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchinetti","sequence":"additional","affiliation":[{"name":"Gynecology & Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"bibr1-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0816-0"},{"key":"bibr2-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-014-1744-2"},{"key":"bibr3-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-010-0274-9"},{"key":"bibr4-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b664"},{"key":"bibr5-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01935.x"},{"key":"bibr6-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01704.x"},{"key":"bibr7-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1111\/head.13023"},{"key":"bibr8-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6874-10-30"},{"key":"bibr9-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.12.030"},{"key":"bibr10-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.09.012"},{"key":"bibr11-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-005-0189-7"},{"key":"bibr12-03331024211029236","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00955.x"},{"key":"bibr13-03331024211029236","unstructured":"The Fetal Medicine Foundation. 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