{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:34:56Z","timestamp":1777491296983,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"International Graduate School of Neuroscience at the Ruhr University Bochum"},{"DOI":"10.13039\/501100003417","name":"German Social Accident Insurance","doi-asserted-by":"crossref","award":["funded professorship for EEK"],"award-info":[{"award-number":["funded professorship for EEK"]}],"id":[{"id":"10.13039\/501100003417","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007200","name":"Medizinische Fakult\u00e4t, Ruhr-Universit\u00e4t Bochum","doi-asserted-by":"publisher","award":["FoRUM grant nr. K120-18"],"award-info":[{"award-number":["FoRUM grant nr. K120-18"]}],"id":[{"id":"10.13039\/501100007200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 874\/A1 and A5, Project No.: 122679504"],"award-info":[{"award-number":["SFB 874\/A1 and A5, Project No.: 122679504"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Aim of the review is to summarize the knowledge about the sensory function and pain modulatory systems in posttraumatic headache and discuss its possible role in patients with posttraumatic headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Posttraumatic headache is the most common complication after traumatic brain injury, and significantly impacts patients\u2019 quality of life. Even though it has a high prevalence, its origin and pathophysiology are poorly understood. Thereby, the existing treatment options are insufficient. Identifying its mechanisms can be an important step forward to develop target-based personalized treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched the PubMed database for studies examining pain modulation and\/or quantitative sensory testing in individuals with headache after brain injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The studies showed heterogenous alterations in sensory profiles (especially in heat and pressure pain perception) compared to healthy controls and headache-free traumatic brain injury-patients. Furthermore, pain inhibition capacity was found to be diminished in subjects with posttraumatic headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Due to the small number of heterogenous studies a distinct sensory pattern for patients with posttraumatic headache could not be identified. Further research is needed to clarify the underlying mechanisms and biomarkers for prediction of development and persistence of posttraumatic headache.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211030496","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T04:04:03Z","timestamp":1629259443000},"page":"73-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Somatosensory dysfunction in patients with posttraumatic headache: A systematic review"],"prefix":"10.1177","volume":"42","author":[{"given":"Julia","family":"Jessen","sequence":"first","affiliation":[{"name":"Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6z\u00fcm S.","family":"\u00d6zg\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"H\u00f6ffken","sequence":"additional","affiliation":[{"name":"Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schwenkreis","sequence":"additional","affiliation":[{"name":"Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Tegenthoff","sequence":"additional","affiliation":[{"name":"Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6162-9414","authenticated-orcid":false,"given":"Elena K","family":"Enax-Krumova","sequence":"additional","affiliation":[{"name":"Department of Neurology, BG University Hospital Bergmannsheil GmbH, Ruhr-University Bochum, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"bibr1-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr2-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413499645"},{"key":"bibr3-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1179\/2042618613Y.0000000053"},{"key":"bibr4-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.1914"},{"key":"bibr5-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.041006559.x"},{"key":"bibr6-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.6.711"},{"key":"bibr7-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00002-2"},{"key":"bibr8-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.08.022"},{"key":"bibr9-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419896368"},{"key":"bibr10-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617710000196"},{"key":"bibr11-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-016-0697-7"},{"key":"bibr12-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01122-5"},{"key":"bibr13-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420909865"},{"key":"bibr14-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0243-8"},{"key":"bibr15-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1111\/head.13812"},{"key":"bibr16-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2015-205429"},{"key":"bibr17-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1051-7"},{"key":"bibr18-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-015-0520-1"},{"key":"bibr19-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002103"},{"key":"bibr20-03331024211030496","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00749"},{"key":"bibr21-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420981688"},{"key":"bibr22-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50312-y"},{"key":"bibr23-03331024211030496","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"bibr24-03331024211030496","volume":"13","author":"Backonja 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