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The headache is frequently debilitating with manifold characters including migraine-like characteristics. Studies suggested that COVID-19 patients with headache vs. those without headache are more likely to have anosmia. We present a pathophysiological hypothesis which may explain this phenomenon, discuss current hypotheses about how the coronavirus SARS-CoV-2 enters the central nervous system and suggest that activation of the trigeminal nerve may contribute to both headache and anosmia in COVID-19.<\/jats:p>","DOI":"10.1177\/03331024211036665","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T02:19:11Z","timestamp":1629339551000},"page":"176-180","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Activation of the trigeminal system as a likely target of SARS-CoV-2 may contribute to anosmia in COVID-19"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8099-3860","authenticated-orcid":false,"given":"Karl","family":"Messlinger","sequence":"first","affiliation":[{"name":"Institute of Physiology and Pathophysiology, Friedrich-Alexander University, Erlangen-Nuernberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"Neuhuber","sequence":"additional","affiliation":[{"name":"Institute of Anatomy and Cell Biology, Friedrich-Alexander University, Erlangen-Nuernberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3499-1506","authenticated-orcid":false,"given":"Arne","family":"May","sequence":"additional","affiliation":[{"name":"Department of Systems Neuroscience, University Medical Center Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"bibr1-03331024211036665","doi-asserted-by":"publisher","DOI":"10.1111\/head.13856"},{"key":"bibr2-03331024211036665","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420966770"},{"key":"bibr3-03331024211036665","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01188-1"},{"key":"bibr4-03331024211036665","doi-asserted-by":"publisher","DOI":"10.1111\/head.13940"},{"key":"bibr5-03331024211036665","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420965157"},{"key":"bibr6-03331024211036665","author":"Meinhardt J","year":"2020","journal-title":"Nat Neurosci. 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