{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:22:06Z","timestamp":1783938126793,"version":"3.55.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, antimigraine drugs targeting the calcitonin gene-related peptide pathway have been approved for clinical use as preventive migraine medication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>We present a case of a 54-year-old male migraine patient, who reported erectile dysfunction as a possible side effect of treatment with galcanezumab, a monoclonal antibody targeting calcitonin gene-related peptide. His potency recovered after treatment discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>As calcitonin gene-related peptide is involved in mammalian penile erection, erectile dysfunction is a conceivable side effect associated with calcitonin gene-related peptide inhibition. Postmarketing surveillance will elucidate the actual incidence of erectile dysfunction in patients using these new antimigraine drugs, and determine whether a causal relationship between calcitonin gene-related peptide inhibition and erectile dysfunction exists. This would be relevant not only because of the direct sexual consequences of erectile dysfunction, but also considering the potential cardiovascular consequences of calcitonin gene-related peptide (receptor) blockade and the association of both migraine and erectile dysfunction with cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Erectile dysfunction might be an overlooked, but reversible side effect in male migraine patients using monoclonal antibodies that inhibit the calcitonin gene-related peptide pathway, including galcanezumab. This paper may raise clinical awareness and suggest that this potential side effect needs to be studied further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211037304","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T05:21:23Z","timestamp":1629264083000},"page":"257-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Could erectile dysfunction be a side effect of CGRP inhibition? A case report"],"prefix":"10.1177","volume":"42","author":[{"given":"Linda","family":"Al-Hassany","sequence":"first","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa de","family":"Vries","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A","family":"Carpay","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tergooi Hospital, Hilversum, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"MaassenVanDenBrink","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"bibr1-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000252808.97649.21"},{"key":"bibr2-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"bibr3-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2020.09.001"},{"key":"bibr4-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1671350"},{"key":"bibr5-03331024211037304","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143527"},{"key":"bibr6-03331024211037304","unstructured":"Eli Lilly and Company.\n                      Galcanezumab (Emgality\u2122): US prescribing information\n                      . 2018. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2018\/761063s000lbl.pdf (accessed 14 March 2021)."},{"key":"bibr7-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30279-9"},{"key":"bibr8-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813440"},{"key":"bibr9-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1177\/1756286420918088"},{"key":"bibr10-03331024211037304","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.549038"},{"key":"bibr11-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37989-2"},{"key":"bibr12-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2.1.95"},{"key":"bibr13-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22519"},{"key":"bibr14-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1111\/head.13510"},{"key":"bibr15-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(93)90608-D"},{"key":"bibr16-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1993.265.2.H581"},{"key":"bibr17-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901430"},{"key":"bibr18-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2016-134073"},{"key":"bibr19-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0979-y"},{"key":"bibr20-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.8.795"},{"key":"bibr21-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.3.283"},{"key":"bibr22-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412439801"},{"key":"bibr23-03331024211037304","volume":"95","author":"Wu SH","year":"2016","journal-title":"Medicine"},{"key":"bibr24-03331024211037304","first-page":"79","volume":"13","author":"Elterman DS","year":"2021","journal-title":"Res Rep Urol"},{"key":"bibr25-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:23:2-3:093"},{"key":"bibr26-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00216.2004"},{"key":"bibr27-03331024211037304","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.08.007"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211037304","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024211037304","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211037304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:13Z","timestamp":1777387753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024211037304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/03331024211037304"],"URL":"https:\/\/doi.org\/10.1177\/03331024211037304","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]}}}