{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:26:43Z","timestamp":1787700403428,"version":"build-2784847793"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["ISCIII - PI16\/01525"],"award-info":[{"award-number":["ISCIII - PI16\/01525"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Spanish Neurological Society","award":["Headache Group Grant 2018"],"award-info":[{"award-number":["Headache Group Grant 2018"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CGRP plays a key role in the transmission and modulation of nociceptive signals and is a critical component in the pathogenesis of migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess saliva as a substrate to measure CGRP by comparing interictal levels in patients with episodic migraine and controls; and to evaluate CGRP\u2019s temporal profile during migraine attacks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational pilot study included young women with episodic migraine and healthy controls. We monitored salivary CGRP-like immunoreactivity (CGRP-LI) during 30 consecutive days and during migraine attacks. We considered six timepoints for the analysis: interictal (72h headache free), preictal (PRE-24h before the attack), ictal (headache onset, after 2h, after 8h), postictal (POST-24h after the attack). CGRP levels were quantified by ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>44 women (22 with episodic migraine, 22 healthy controls) were recruited. Differences in interictal salivary levels of CGRP between patients and controls (Me [IQR]: 98.0 [80.3] (95% CI 56.6, 124.0) vs. 54.3 [44.0] (95% CI 42.2, 70.1)\u2009pg\/mL, p\u2009=\u20090.034) were found. An increase in CGRP levels during migraine attacks was detected (pre:169.0 [95% CI 104.2\u2013234.0]; headache onset: 247.0 [181.9\u2013312.0]; after 2h: 143.0 [77.6\u2013208.0]; after 8h: 169.0 [103.5\u2013234.0], post: 173.0 [107.8\u2013238.0]). Patients were classified as having CGRP-dependent (79.6%) and non-CGRP dependent migraine attacks (20.4%) according to the magnitude of change between preictal and ictal phase. Accompanying symptoms such as photophobia and phonophobia were significantly associated to the first group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salivary CGRP-LI levels, which interictally are elevated in episodic migraine patients, usually increase during a migraine attack in the majority of patients. However, not every attack is CGRP-dependent, which in turn, might explain different underlying pathophysiology and response to treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211040467","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T21:47:52Z","timestamp":1633384072000},"page":"186-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":67,"title":["Salivary CGRP can monitor the different migraine phases: CGRP (in)dependent attacks"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-9401","authenticated-orcid":false,"given":"Alicia","family":"Alpuente","sequence":"first","affiliation":[{"name":"Headache Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain."},{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-2007","authenticated-orcid":false,"given":"Victor J","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Asskour","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-0267","authenticated-orcid":false,"given":"Edoardo","family":"Caronna","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain."},{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Torres-Ferrus","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain."},{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Pozo-Rosich","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain."},{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"bibr1-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"bibr2-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.12174"},{"key":"bibr3-03331024211040467","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180622122938"},{"key":"bibr4-03331024211040467","author":"Frederiksen SD.","journal-title":"Headache"},{"key":"bibr5-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280213"},{"key":"bibr6-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0003-1"},{"key":"bibr7-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32504-8"},{"key":"bibr8-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000831"},{"key":"bibr9-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0216-y"},{"key":"bibr10-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1990.1001039.x"},{"key":"bibr11-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01717.x"},{"key":"bibr12-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1994.1402134.x"},{"key":"bibr13-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.12250"},{"key":"bibr14-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00294.x"},{"key":"bibr15-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2009.01523.x"},{"key":"bibr16-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.13211"},{"key":"bibr17-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21131-4"},{"key":"bibr18-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1990.hed3002069.x"},{"key":"bibr19-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00627-3"},{"key":"bibr20-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1211\/0022357011778098"},{"key":"bibr21-03331024211040467","first-page":"1","volume-title":"Cephalalgia","volume":"38","author":"Headache Classification Committee of the International Headache Society","year":"2018"},{"key":"bibr22-03331024211040467","unstructured":"Pinheiro J, Bates D, DebRoy S, et\u00a0al. Package \u2018nlme\u2019. Linear and nonlinear mixed effects models, R package version 3.1-152."},{"key":"bibr23-03331024211040467","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. 2021. Available at: http:\/\/www.R-project.org\/ (accessed 2020)."},{"key":"bibr24-03331024211040467","first-page":"10","volume":"35","author":"Wickham H.","year":"2009","journal-title":"Media"},{"key":"bibr25-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00232-3"},{"key":"bibr26-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.017"},{"key":"bibr27-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419856640"},{"key":"bibr28-03331024211040467","author":"Seybold VS.","journal-title":"Handb Exp Pharmacol"},{"key":"bibr29-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1038\/384560a0"},{"key":"bibr30-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb72"},{"key":"bibr31-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0883-x"},{"key":"bibr32-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00552.x"},{"key":"bibr33-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.1.132"},{"key":"bibr34-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301246"},{"key":"bibr35-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.13300"},{"key":"bibr36-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww097"},{"key":"bibr37-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822550e2"},{"key":"bibr38-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.13929"},{"key":"bibr39-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000702"},{"key":"bibr40-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80014-0"},{"key":"bibr41-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409351807"},{"key":"bibr42-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420949858"},{"key":"bibr43-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20605"},{"key":"bibr44-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1991.tb00281.x"},{"key":"bibr45-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709038"},{"key":"bibr46-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000771"},{"key":"bibr47-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30083-2"},{"key":"bibr48-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417736900"},{"key":"bibr49-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.13081"},{"key":"bibr50-03331024211040467","doi-asserted-by":"publisher","DOI":"10.1111\/head.13529"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211040467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024211040467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211040467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:14Z","timestamp":1777387754000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024211040467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/03331024211040467"],"URL":"https:\/\/doi.org\/10.1177\/03331024211040467","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.11.18.20233841","asserted-by":"object"}]},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,4]]}}}