{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:37:54Z","timestamp":1788431874588,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"4-5","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_173193\/1\u201d"],"award-info":[{"award-number":["32003B_173193\/1\u201d"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies propose that brain energy deficit might be partially involved in the pathophysiology of migraine. Previously, studies demonstrated that ketogenic diet causes a substantial reduction in migraine frequency. Since the ketogenic diet is restricting and its adherence is difficult, we proposed to supplement ketone bodies exogenously to provide a prophylactic effect in migraineurs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the prophylactic effect of exogenous DL-beta-hydroxybutyrate supplementation in episodic migraineurs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A double-blind, placebo-controlled, randomised crossover trial was conducted, involving 41 patients with episodic migraine. Patients were randomised 1:1 into placebo or beta-hydroxybutyrate group before entering the first treatment period. Each treatment period was 12 weeks long, followed by four weeks of washout phase and four weeks of run-in phase before entering into the corresponding second treatment period. The primary endpoint was the number of migraine days in the last four weeks of treatment, adjusted for baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed no clinically significant amelioration of migraine frequency or intensity under DL-beta-hydroxybutyrate treatment as compared to placebo regarding number of migraine days (mean difference [95% CI]: \u22121.1[\u22125.07, 2.85]), migraine intensity (0\u201310 VAS: 1.5[\u22120.8, 3.7]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The selected dose of supplemented exogenous DL-beta-hydroxybutyrate did not demonstrate efficacy in episodic migraineurs. ClinicalTrials.gov Identifier: NCT03132233<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211043792","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T08:11:10Z","timestamp":1632125470000},"page":"302-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of exogenous beta-hydroxybutyrate for preventive treatment in episodic migraine: A single-centred, randomised, placebo-controlled, double-blind crossover trial"],"prefix":"10.1177","volume":"42","author":[{"given":"Niveditha","family":"Putananickal","sequence":"first","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-6506","authenticated-orcid":false,"given":"Elena C","family":"Gross","sequence":"additional","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Lena","family":"Orsini","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Basel Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Hafner","sequence":"additional","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanya","family":"Gocheva","sequence":"additional","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Basel Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina C","family":"Henzi","sequence":"additional","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Rubino","sequence":"additional","affiliation":[{"name":"Division of Neuropaediatrics, University of Basel Children's Hospital, University of Basel, 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