{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T12:39:31Z","timestamp":1787229571304,"version":"build-2736575974"},"reference-count":80,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Headache in patients with moyamoya disease is an under-addressed topic in the medical literature. Delay in the diagnosis of moyamoya disease or inappropriate treatment of headache could lead to devastating cerebrovascular outcome. With the evolving understanding of moyamoya disease, migraine pathophysiology, and various migraine-specific medications that have become available, it is crucial to provide an updated overview on this topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed for keywords including moyamoya disease, moyamoya syndrome, headache in moyamoya, surgical revascularization, surgical bypass, migraine and moyamoya, and calcitonin gene-related peptide (CGRP). We summarized the literature and provide a comprehensive review of the headache presentation, possible mechanisms, the impact of various surgical revascularizations on headache in patients with moyamoya disease, and the medical management of headache incorporating novel migraine-specific treatments. Results and conclusion: The most common headache phenotype is migraine; tension-type headache, hemiplegic migraine, and cluster headache have also been reported. Most patients experience improvement of headache after surgical revascularization, though some patients report worsening, or new-onset headache after surgery. Given the complexity of moyamoya disease, careful consideration of different types of medical therapy for headache is necessary to improve the quality of life while not increasing the risk of adverse cerebrovascular events. More prospective studies are warranted to better understand and manage headache in patients with moyamoya disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211056250","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T06:08:21Z","timestamp":1637129301000},"page":"542-552","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation and treatment of headache associated with moyamoya disease \u2013 a narrative review"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-7172","authenticated-orcid":false,"given":"Chia-Chun","family":"Chiang","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2703-3497","authenticated-orcid":false,"given":"Adnan H","family":"Shahid","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M","family":"Harriott","sequence":"additional","affiliation":[{"name":"Department of Neurology, Massachusetts General Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen E","family":"Tietjen","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Toledo, Toledo, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis E","family":"Savastano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Klaas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanzino","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"bibr1-03331024211056250","first-page":"229","volume":"70","author":"Hishikawa T","year":"2016","journal-title":"Acta Med Okayama"},{"key":"bibr2-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090076012"},{"key":"bibr3-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"bibr4-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000176066.33797.82"},{"key":"bibr5-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.2000.00300.x"},{"key":"bibr6-03331024211056250","first-page":"e10994","volume":"12","author":"Berry JA","year":"2020","journal-title":"Cureus"},{"key":"bibr7-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0883073817718730"},{"key":"bibr8-03331024211056250","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3171\/jns.2005.103.3.0439","volume":"103","author":"Seol HJ","year":"2005","journal-title":"J Neurosurg"},{"key":"bibr9-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416643516"},{"key":"bibr10-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-8467(97)00041-3"},{"key":"bibr11-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr12-03331024211056250","doi-asserted-by":"publisher","DOI":"10.3171\/2018.10.JNS181139"},{"key":"bibr13-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0181-8"},{"key":"bibr14-03331024211056250","first-page":"718","volume":"147","author":"Bernstein AL.","year":"1993","journal-title":"Am J Dis Child"},{"key":"bibr15-03331024211056250","doi-asserted-by":"publisher","DOI":"10.4103\/1658-354X.144104"},{"key":"bibr16-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.inat.2014.07.001"},{"key":"bibr17-03331024211056250","doi-asserted-by":"crossref","unstructured":"Siddiqui MR, Khan SU, Hoque MA, et\u00a0al.  Moyamoya disease presented as a case of hemiplegic migraine.\n                      BMJ Case Rep\n                      2010; 2010: bcr0220102764. doi: 10.1136\/bcr.02.2010.2764.","DOI":"10.1136\/bcr.02.2010.2764"},{"key":"bibr18-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1999.tb01050.x"},{"key":"bibr19-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-008-0081-3"},{"key":"bibr20-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2019.01.004"},{"key":"bibr21-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1940.01210040002001"},{"key":"bibr22-03331024211056250","doi-asserted-by":"publisher","DOI":"10.2174\/092986732304160204181543"},{"key":"bibr23-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16658301"},{"key":"bibr24-03331024211056250","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.ra.2014-0307"},{"key":"bibr25-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy300"},{"key":"bibr26-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.03.012"},{"key":"bibr27-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002008"},{"key":"bibr28-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.08.005"},{"key":"bibr29-03331024211056250","first-page":"39","volume":"64","author":"Bohara M","year":"2015","journal-title":"Hiroshima J Med Sci"},{"key":"bibr30-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-020-04991-y"},{"key":"bibr31-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018563"},{"key":"bibr32-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.nec.2010.03.008"},{"key":"bibr33-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180051501"},{"key":"bibr34-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-014-2408-5"},{"key":"bibr35-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-16-S1-A73"},{"key":"bibr36-03331024211056250","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.31.708"},{"key":"bibr37-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21981"},{"key":"bibr38-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(12)80007-6"},{"key":"bibr39-03331024211056250","first-page":"272","volume":"15","author":"Liu X-F","year":"1999","journal-title":"Schweiz Arch Neurol Psychiatr"},{"key":"bibr40-03331024211056250","doi-asserted-by":"publisher","DOI":"10.3171\/2011.11.JNS11944"},{"key":"bibr41-03331024211056250","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.cr2012-0134"},{"key":"bibr42-03331024211056250","first-page":"e4426","volume":"11","author":"Azzam DB","year":"2019","journal-title":"Cureus"},{"key":"bibr43-03331024211056250","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.605636"},{"key":"bibr44-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.05.228"},{"key":"bibr45-03331024211056250","first-page":"142","volume":"100","author":"Scott RM","year":"2004","journal-title":"J Neurosurg"},{"key":"bibr46-03331024211056250","doi-asserted-by":"crossref","unstructured":"Shirane R, Fujimura M. Headache in moyamoya disease. In: Cho BK and Tominaga T (eds)\n                      Moyamoya disease update\n                      , 1st edn. Tokyo: Springer Japan, 2010, pp.101\u2013104.","DOI":"10.1007\/978-4-431-99703-0_17"},{"key":"bibr47-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2005.03997.x"},{"key":"bibr48-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2012.02096.x"},{"key":"bibr49-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2019.10.023"},{"key":"bibr50-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2001.00168.x"},{"key":"bibr51-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1159\/000481252"},{"key":"bibr52-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414531156"},{"key":"bibr53-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13919"},{"key":"bibr54-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006573"},{"key":"bibr55-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1590\/1516-3180.2016.0165050916"},{"key":"bibr56-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006572"},{"key":"bibr57-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1111\/head.13796"},{"key":"bibr58-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.045"},{"key":"bibr59-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.00821.x"},{"key":"bibr60-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01536.x"},{"key":"bibr61-03331024211056250","first-page":"953","volume":"21","author":"Becker WJ.","year":"2015","journal-title":"Continuum (Minneap Minn)"},{"key":"bibr62-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000718"},{"key":"bibr63-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1044-6"},{"key":"bibr64-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410370873"},{"key":"bibr65-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006641"},{"key":"bibr66-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz134"},{"key":"bibr67-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182535d20"},{"key":"bibr68-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03527.x"},{"key":"bibr69-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32544-7"},{"key":"bibr70-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30234-9"},{"key":"bibr71-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417736900"},{"key":"bibr72-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2020.06.019"},{"key":"bibr73-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1111\/head.13951"},{"key":"bibr74-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-0979-y"},{"key":"bibr75-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001649"},{"key":"bibr76-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25831"},{"key":"bibr77-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420956692"},{"key":"bibr78-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414544976"},{"key":"bibr79-03331024211056250","doi-asserted-by":"crossref","unstructured":"Saely S, Croteau D, Jawidzik L, et\u00a0al.  Hypertension: A new safety risk for patients treated with erenumab.\n                      Headache\n                      2021; 61: 202\u2013208.","DOI":"10.1111\/head.14051"},{"key":"bibr80-03331024211056250","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420950484"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211056250","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024211056250","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211056250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:19Z","timestamp":1777387759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024211056250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":80,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/03331024211056250"],"URL":"https:\/\/doi.org\/10.1177\/03331024211056250","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]}}}