{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:36:27Z","timestamp":1777491387263,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","award":["CEHEAD"],"award-info":[{"award-number":["CEHEAD"]}],"id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["9039-00067B"],"award-info":[{"award-number":["9039-00067B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In the general population 4% have never experienced a headache. Freedom from headache could be due to distinctive protective mechanisms or a lack of environmental risk factors for headache. Isosorbide-5-mononitrate is an organic nitrate which in the body is metabolised to nitric oxide. The nitric oxide pathway plays a crucial role in the primary headaches. We hypothesized that people who are free from headache are protected by distinctive mechanisms in the nitric oxide pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an observer blinded case-control study using nitric oxide to provoke a headache. 32 headache free male participants and 26 randomly selected male controls received 60\u2009mg Isosorbide-5-mononitrate orally on the study day. Participants fill out a headache diary with headache intensity and characteristics until 12 hours after administration of Isosorbide-5-mononitrate. Primary endpoint were areas under the curve of headache intensity score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 58 participants completed the study. There was no significant difference in headache incidence, headache intensity score or migraine-like attack between headache free participants and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We show that men who have never experienced a headache develop a headache when provoked with Isosorbide-5-mononitrate. This indicates that freedom from headache in men is not related to the nitric oxide pathway which is involved in the primary headache disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211060002","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T23:39:09Z","timestamp":1638920349000},"page":"598-607","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Headache provocation by nitric oxide in men who have never experienced a headache"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-8045","authenticated-orcid":false,"given":"Isa Amalie","family":"Olofsson","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine","family":"Falkenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Folkmann","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"bibr1-03331024211060002","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00468.x"},{"key":"bibr2-03331024211060002","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90147-2"},{"key":"bibr3-03331024211060002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1981.tb00016.x"},{"key":"bibr4-03331024211060002","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420920653"},{"key":"bibr5-03331024211060002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"bibr6-03331024211060002","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.013"},{"key":"bibr7-03331024211060002","first-page":"893","volume":"237","author":"Ignarro LJ","year":"1986","journal-title":"J Pharmacol Exp 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