{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:11:31Z","timestamp":1788999091003,"version":"build-2803163510"},"reference-count":17,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Gerencia Regional de Salud (GRS) Castilla y Leon","award":["GRS 2289\/A\/2020"],"award-info":[{"award-number":["GRS 2289\/A\/2020"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Headache is a frequent symptoms of coronavirus disease 2019 (COVID-19). Its long-term evolution remains unknown. We aim to evaluate the long-term duration of headache in patients that presented headache during the acute phase of COVID-19.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a post-hoc multicenter ambisective study including patients from six different third-level hospitals between 1 March and 27 April 2020. Patients completed 9 months of neurological follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 905 patients. Their median age was 51 (IQR 45\u201365), 66.5% were female, and 52.7% had a prior history of primary headache. The median duration of headache was 14 (6\u201339) days; however, the headache persisted after 3 months in 19.0% (95% CI: 16.5\u201321.8%) and after 9 months in 16.0% (95% confidence interval: 13.7\u201318.7%). Headache intensity during the acute phase was associated with a more prolonged duration of headache (Hazard ratio 0.655; 95% confidence interval: 0.582\u20130.737).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The median duration of headache was 2 weeks, but in approximately a fifth of patients it became persistent and followed a chronic daily pattern.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024211068074","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T06:38:38Z","timestamp":1644907118000},"page":"804-809","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":82,"title":["Post-COVID-19 persistent headache: A multicentric 9-months follow-up study of 905 patients"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garcia-Azorin","sequence":"first","affiliation":[{"name":"Hospital Clinico Universitario de Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-7808","authenticated-orcid":false,"given":"Almudena","family":"Layos-Romero","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital General de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-682X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Porta-Etessam","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital San Carlos, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Madrid, Spain"},{"name":"Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A","family":"Membrilla","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital \u201cLa Paz\u201d, Madrid, Spain"},{"name":"La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-0267","authenticated-orcid":false,"given":"Edoardo","family":"Caronna","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"},{"name":"Headache Research Group, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-1503","authenticated-orcid":false,"given":"Alicia","family":"Gonzalez-Martinez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa, Department of Neurology, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro Sierra","family":"Mencia","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario de Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Segura","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital General de Albacete, Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gonzalez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital San Carlos, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria San Carlos (IdISSC), Madrid, Spain"},{"name":"Universidad Complutense de Madrid, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"D\u00edaz-de-Ter\u00e1n","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital \u201cLa Paz\u201d, Madrid, Spain"},{"name":"La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-2007","authenticated-orcid":false,"given":"Victor J","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Headache Research Group, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Gago-Veiga","sequence":"additional","affiliation":[{"name":"Hospital Universitario de la Princesa, Department of Neurology, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ballv\u00e9","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-3386","authenticated-orcid":false,"given":"Javier","family":"Trigo L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario de Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Sastre-Real","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital \u201cLa Paz\u201d, Madrid, Spain"},{"name":"La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnau","family":"Llaurad\u00f3","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Cornejo","sequence":"additional","affiliation":[{"name":"Valladolid East Primary Care Basic Health Area, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cd\u00f1igo","family":"de Lorenzo","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital \u201cLa Paz\u201d, Madrid, Spain"},{"name":"La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-6002","authenticated-orcid":false,"given":"\u00c1ngel","family":"Guerrero-Peral","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario de Valladolid, Headache Unit, Department of Neurology, Valladolid, Spain"},{"name":"Department of Medicine, University of Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Pozo-Rosich","sequence":"additional","affiliation":[{"name":"Headache Unit, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Barcelona, Spain"},{"name":"Headache Research Group, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f3noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"bibr1-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009937"},{"key":"bibr2-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1111\/head.13902"},{"key":"bibr3-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94220-6"},{"key":"bibr4-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1111\/head.13967"},{"key":"bibr5-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420965157"},{"key":"bibr6-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14718"},{"key":"bibr7-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.12603"},{"key":"bibr8-03331024211068074","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.37.289.27110"},{"key":"bibr9-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"bibr10-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.0830"},{"key":"bibr11-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1111\/head.14197"},{"key":"bibr12-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040297"},{"key":"bibr13-03331024211068074","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.nrl.2020.07.007","volume":"35","author":"Moroll\u00f3n N","year":"2020","journal-title":"Neurologia"},{"key":"bibr14-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dad5de"},{"key":"bibr15-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"bibr16-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2015"},{"key":"bibr17-03331024211068074","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.02.006"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211068074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024211068074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024211068074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:22Z","timestamp":1777387762000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024211068074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/03331024211068074"],"URL":"https:\/\/doi.org\/10.1177\/03331024211068074","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,15]]}}}