{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:53:12Z","timestamp":1791546792712,"version":"4.3.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005881","name":"Emberi Eroforr\u00e1sok Miniszt\u00e9riuma","doi-asserted-by":"publisher","award":["Higher Education Institutional Excellence Program"],"award-info":[{"award-number":["Higher Education Institutional Excellence Program"]}],"id":[{"id":"10.13039\/501100005881","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["GINOP-2.3.2-15-2016-00034"],"award-info":[{"award-number":["GINOP-2.3.2-15-2016-00034"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["K119597"],"award-info":[{"award-number":["K119597"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["K127988"],"award-info":[{"award-number":["K127988"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>TWIK-related spinal cord potassium channel (TRESK) background potassium channels have a key role in controlling resting membrane potential and excitability of sensory neurons. A frameshift mutation leading to complete loss of TRESK function has been identified in members of a family suffering from migraine with aura. In the present study, we examined the role of TRESK channels on nociceptor function in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Calcium imaging was used to investigate the role of TRESK channels in the modulation of the response evoked by transient receptor potential vanilloid 1 (TRPV1) receptor stimulation in dorsal root ganglion neurons. Release of calcitonin gene-related peptide from trigeminal afferents and changes in meningeal blood flow were also measured. Experiments were performed on wild-type and TRESK knockout animals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Inhibition of TRESK increased the TRPV1-mediated calcium signal in dorsal root ganglion neurons and potentiated capsaicin-induced increases in calcitonin gene-related peptide release and meningeal blood flow. Activation of TRESK decreased the capsaicin sensitivity of sensory neurons, leading to an attenuation of capsaicin-induced increase in meningeal blood flow. In TRESK knockout animals, TRPV1-mediated nociceptive reactions were unaffected by pretreatment with TRESK modulators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pharmacological manipulation of TRESK channels influences the TRPV1-mediated functions of nociceptors. Altered TRESK function might contribute to trigeminal nociceptor sensitization in migraine patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0333102421989261","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T23:34:45Z","timestamp":1612222485000},"page":"827-838","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["TRESK background potassium channel modifies the TRPV1-mediated nociceptor excitability in sensory neurons"],"prefix":"10.1177","volume":"41","author":[{"given":"Mikl\u00f3s","family":"Lengyel","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominika","family":"Hajdu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Dobolyi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Rosta","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e1bor","family":"Czirj\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria","family":"Dux","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Enyedi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"bibr1-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0807-1"},{"key":"bibr2-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0003-1"},{"key":"bibr3-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21607"},{"key":"bibr4-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.05.016"},{"key":"bibr5-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-07-02468.1988"},{"key":"bibr6-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.050633"},{"key":"bibr7-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.986"},{"key":"bibr8-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.06.012"},{"key":"bibr9-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1111\/head.13081"},{"key":"bibr10-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1111\/head.13529"},{"key":"bibr11-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010814-124701"},{"key":"bibr12-0333102421989261","doi-asserted-by":"publisher","DOI":"10.3390\/ph9040072"},{"key":"bibr13-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416654883"},{"key":"bibr14-0333102421989261","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010342"},{"key":"bibr15-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312229200"},{"key":"bibr16-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00629.2005"},{"key":"bibr17-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.08.062"},{"key":"bibr18-0333102421989261","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2216"},{"key":"bibr19-0333102421989261","doi-asserted-by":"crossref","unstructured":"Lengyel M, Dobolyi A, Czirj\u00e1k G, et\u00a0al. 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