{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:23:14Z","timestamp":1781796194410,"version":"3.54.5"},"reference-count":28,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020R1A2B5B01001826"],"award-info":[{"award-number":["NRF-2020R1A2B5B01001826"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objective<\/jats:title>\n                    <jats:p>We aimed to provide real-world data on the effectiveness of an anti-calcitonin gene-related peptide monoclonal antibody administered for treating migraine in Korean patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively recruited patients with migraine who received galcanezumab treatment at a single university hospital from June 2020 to April 2021. The treatment response was assessed after three consecutive monthly injections. A 50% responder rate was evaluated based on \u226550% reduction in the number of moderate\/severe headache days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 87 patients were included in the analysis. Most patients were women (83.9%). They had a mean age of 41.7\u2009\u00b1\u200912.3 years (range 17\u201372). Sixty-five patients (74.7%) had chronic migraine, 35 patients (40.2%) had a history of medication-overuse headache, and 32 patients (36.8%) were previously unresponsive to or found intolerable five classes of preventive medication. After three months of treatment, mean changes in numbers of monthly headache days, moderate\/severe headache days, crystal clear days, and days of acute medication use were \u22127.2\u2009\u00b1\u20098.43, \u22124.3\u2009\u00b1\u20099.76, 7.3\u2009\u00b1\u20098.50, and \u22124.1\u2009\u00b1\u20097.93, respectively. The 50% responder rates were 58.3%, 44.2%, and 40.6% for patients with unsuccessful previous use of 0\u20131, 2\u20134, and 5 preventive medication classes, respectively. Headache Impact Test-6 and Migraine Disability Assessment Test scores also decreased (\u22124.4\u2009\u00b1\u20098.09 and \u221232.9\u2009\u00b1\u200977.04, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our cohort, the effectiveness and safety of galcanezumab were comparable with those reported in clinical trials, whereas a higher response rate was observed in the difficult-to-treat patient subset than that reported in trials. We provide real-world evidence of galcanezumab treatment benefits in Asian patients with migraine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221076481","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T07:21:27Z","timestamp":1647588087000},"page":"705-714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":31,"title":["Real-world efficacy of galcanezumab for the treatment of migraine in Korean patients"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-7571","authenticated-orcid":false,"given":"Soonwook","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Neurology, Inha University Hospital, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-8527","authenticated-orcid":false,"given":"Young-Eun","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-1969","authenticated-orcid":false,"given":"Mi Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"bibr1-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.224212"},{"key":"bibr2-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31946-4"},{"key":"bibr3-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14114"},{"key":"bibr4-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32534-0"},{"key":"bibr5-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1212"},{"key":"bibr6-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418779543"},{"key":"bibr7-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006640"},{"key":"bibr8-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30279-9"},{"key":"bibr9-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2020.1815181"},{"key":"bibr10-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr11-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410379890"},{"key":"bibr12-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00305-5"},{"key":"bibr13-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0583-8"},{"key":"bibr14-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-015-0552-2"},{"key":"bibr15-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418758283"},{"key":"bibr16-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420941839"},{"key":"bibr17-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307149"},{"key":"bibr18-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1111\/head.14096"},{"key":"bibr19-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419844711"},{"key":"bibr20-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419896760"},{"key":"bibr21-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10523-8"},{"key":"bibr22-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01247-1"},{"key":"bibr23-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007497"},{"key":"bibr24-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420966658"},{"key":"bibr25-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04670-5"},{"key":"bibr26-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1111\/head.14036"},{"key":"bibr27-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14828"},{"key":"bibr28-03331024221076481","doi-asserted-by":"publisher","DOI":"10.1177\/2515816320932573"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024221076481","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024221076481","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024221076481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:27Z","timestamp":1777387767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024221076481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/03331024221076481"],"URL":"https:\/\/doi.org\/10.1177\/03331024221076481","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]}}}