{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:13:11Z","timestamp":1790719991359,"version":"4.1.0"},"reference-count":11,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100030922","name":"Research Institute of the McGill University Health Centre","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100030922","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["282228"],"award-info":[{"award-number":["282228"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["295639"],"award-info":[{"award-number":["295639"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Headaches with marked, specific response to indomethacin occur in children, but the phenotypic spectrum of this phenomenon has not been well-studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed pediatric patients with headache showing \u226580% improvement with indomethacin, from seven academic medical centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 32 pediatric patients (16 females). Mean headache onset age was 10.9 y (range 2\u201316 y). Headache syndromes included hemicrania continua (n\u2009=\u200913), paroxysmal hemicrania (n\u2009=\u200910), primary stabbing headache (n\u2009=\u20092), short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (n\u2009=\u20091), primary exercise headache (n\u2009=\u20091) and primary cough headache (n\u2009=\u20091). Adverse events were reported in 13, most commonly gastrointestinal symptoms, which often improved with co-administration of gastro-protective agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Indomethacin-responsive headaches occur in children and adolescents, and include headache syndromes, such as primary cough headache, previously thought to present only in adulthood. The incidence of adverse events is high, and patients must be co-treated with a gastroprotective agent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221076483","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T10:20:05Z","timestamp":1647598805000},"page":"793-797","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The spectrum of indomethacin-responsive headaches in children and adolescents"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7831-4593","authenticated-orcid":false,"given":"Kenneth A","family":"Myers","sequence":"first","affiliation":[{"name":"Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"},{"name":"Division of Child Neurology, Department of Pediatrics, Montreal Children\u2019s Hospital, McGill University, Montreal, Quebec, Canada"},{"name":"Department of Neurology and Neurosurgery, Montreal Children\u2019s Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Barmherzig","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichelle R","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoussen","family":"Berrahmoune","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ingelmo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology, McGill University Health Center, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Saint-Martin","sequence":"additional","affiliation":[{"name":"Department of Radiology, McGill University Health Center, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsheen Q","family":"Khan","sequence":"additional","affiliation":[{"name":"Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kouri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Morris","sequence":"additional","affiliation":[{"name":"Child and Adolescent Headache Program, University of California San Francisco, San Francisco, CA, USA"},{"name":"Department of Child Neurology, Cardinal Glennon Children's Hospital, St. Louis University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D","family":"Hershey","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Kacperski","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle A","family":"Kabbouche","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Cincinnati Children\u2019s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology, McGill University Health Center, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi R","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Louisiana State University Health Sciences Center and Children\u2019s Hospital New Orleans, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Marissa","family":"Lagman-Bartolome","sequence":"additional","affiliation":[{"name":"Division of Neurology, Hospital for Sick Children and Women's College Hospital, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy A","family":"Gelfand","sequence":"additional","affiliation":[{"name":"Child and Adolescent Headache Program, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-8889","authenticated-orcid":false,"given":"Christina L","family":"Szperka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena L","family":"Orr","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, Alberta Children\u2019s Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"bibr1-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03793.x"},{"key":"bibr2-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30299-5"},{"key":"bibr3-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0516-y"},{"key":"bibr4-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1111\/head.12054"},{"key":"bibr5-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-011-0315-7"},{"key":"bibr6-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1053\/spen.2001.23328"},{"key":"bibr7-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01813.x"},{"key":"bibr8-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr9-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00439.x"},{"key":"bibr10-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.1.25"},{"key":"bibr11-03331024221076483","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01719.x"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024221076483","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024221076483","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024221076483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:27Z","timestamp":1777387767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024221076483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,18]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/03331024221076483"],"URL":"https:\/\/doi.org\/10.1177\/03331024221076483","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,18]]}}}