{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:00:22Z","timestamp":1782918022243,"version":"3.54.5"},"reference-count":44,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["VGH 108-C-092, VGH 109-C-096, and VGH 110-C-111"],"award-info":[{"award-number":["VGH 108-C-092, VGH 109-C-096, and VGH 110-C-111"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"crossref","award":["MOST 109-2314-B-075 -054, MOST 110-2314-B-075 -041"],"award-info":[{"award-number":["MOST 109-2314-B-075 -054, MOST 110-2314-B-075 -041"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The role of the NOTCH3 p.R544C variant, the predominant variant of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy in multiple East Asian regions, in migraine is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Migraine patients (n\u2009=\u20092,884) (2,279F\/605M, mean age 38.8\u2009\u00b1\u200911.7 years), including 324 (11.2%) with migraine with aura, were prospectively enrolled by headache specialists according to the International Classification of Headache Disorders criteria. These patients and 3,502 population controls free of stroke, dementia, and headache were genotyped for NOTCH3 p.R544C by TaqMan genotyping assay or Axiom Genome-Wide TWB 2.0 Array. Clinical manifestations and brain magnetic resonance images were examined and compared between migraine patients with and without NOTCH3 p.R544C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-two migraine patients (1.1%) and 36 controls (1.0%) harbored the p.R544C variant, and the percentages were comparable among migraine patients without and with aura, and controls (1.2%, vs. 0.6% vs. 1.0%, p\u2009=\u20090.625). Overall, migraine patients with and without the p.R544C variant had similar percentages of migraine with aura, headache characteristics, frequencies and disabilities. However, those with p.R544C were less likely to have pulsatile headaches (50.0% vs. 68.2%, p\u2009=\u20090.028), and more likely to have moderate to severe white matter hyperintensities in the external capsule (18.8% vs. 1.2%, p\u2009=\u20090.006) and anterior temporal lobe (12.5% vs. 0%, p\u2009=\u20090.008).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that NOTCH3 p.R544C does not increase the risk of migraine with aura, or migraine as a whole, and generally does not alter clinical manifestations of migraine. The role of NOTCH3 variants, as well as potential influences from ethnicity or modifier genes, in migraine needs to be further clarified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221080891","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T10:27:26Z","timestamp":1647599246000},"page":"888-898","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Mutation screening and association analysis of\n                    <i>NOTCH3<\/i>\n                    p.R544C in patients with migraine with or without aura"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-3432","authenticated-orcid":false,"given":"Yen-Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chu","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Shiang","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiing-Feng","family":"Lirng","sequence":"additional","affiliation":[{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ta","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-6555","authenticated-orcid":false,"given":"Kuan-Lin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, 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