{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:54:58Z","timestamp":1793066098484,"version":"4.5.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T00:00:00Z","timestamp":1648166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta-analysis compared pressure pain sensitivity in trigeminal, cervical spine and remote pain-free areas between migraine patients and headache-free controls considering diagnosis (episodic versus chronic) and sex. Databases and data treatment: Electronic databases were searched for cross-sectional or prospective case-control studies comparing pressure pain thresholds between migraine and headache-free controls. Data were extracted by two reviewers. The risk of bias and methodological quality was assessed by Newcastle-Ottawa Quality Assessment Scale. Meta-analyses of trigeminal, extra-trigeminal (cervical spine) and remote pain-free areas were compared. Frequency of migraine and sex were taken into account. Mean differences (MD) and random effects were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighteen studies were included. Patients with migraine showed lower pressure pain thresholds than headache-free controls: trigeminal (MD \u221271.33\u2009kPa, 95%CI \u221292.14 to \u221250.53), cervical spine (MD \u221268.50\u2009kPa, 95%CI \u221284.67 to \u221252.33), and remote pain-free (MD \u221262.49\u2009kPa, 95%CI \u221299.52 to \u221225.45) areas. Differences were consistently significant for episodic migraine in all locations, but only significant in the trigeminal area for chronic migraine (MD \u221267.36\u2009kOPa, 95%CI \u2212101.31 to \u221233.42). Overall, women had lower pressure pain thresholds than men. The methodological quality of most studies (66.7%) was good. The results showed a high heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta-analysis found low to high quality evidence showing lower pressure pain thresholds in trigeminal, extra-trigeminal, and remote pain-free areas in migraine sufferers when compared with headache-free controls. Hypersensitivity to pressure pain locally and widespread was consistently observed in episodic migraine, but locally in chronic migraine as compared to headache-free controls. Women with migraine were more sensitive than men. Registration number: https:\/\/doi.org\/10.17605\/OSF.IO\/YJTAK<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221084217","type":"journal-article","created":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T05:10:58Z","timestamp":1648185058000},"page":"966-980","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Localized and widespread pressure pain hypersensitivity in patients with episodic or chronic migraine: A systematic review and meta-analysis"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-9690","authenticated-orcid":false,"given":"C\u00e9sar","family":"Fern\u00e1ndez-de-las-Pe\u00f1as","sequence":"first","affiliation":[{"name":"Department of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Universidad Rey Juan Carlos (URJC), Alcorc\u00f3n, Madrid, Spain."},{"name":"C\u00e1tedra Institucional en Docencia, Cl\u00ednica e Investigaci\u00f3n en Fisioterapia, Terapia Manual, Punci\u00f3n Seca y Ejercicio Terap\u00e9utico, Universidad Rey Juan Carlos, Madrid, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos J","family":"Navarro-Santana","sequence":"additional","affiliation":[{"name":"Faculty of Health, Universidad Cat\u00f3lica de \u00c1vila, \u00c1vila, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Curiel-Montero","sequence":"additional","affiliation":[{"name":"Department of Department of Nursing, Pharmacology and Physical Therapy, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Plaza-Manzano","sequence":"additional","affiliation":[{"name":"Radiology, Rehabilitation and Physiotherapy Department, Universidad Complutense de Madrid, Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Alburquerque-Send\u00edn","sequence":"additional","affiliation":[{"name":"Department of Department of Nursing, Pharmacology and Physical Therapy, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"},{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC), C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana P","family":"Rodrigues-de-Souza","sequence":"additional","affiliation":[{"name":"Department of Department of Nursing, Pharmacology and Physical Therapy, Universidad de C\u00f3rdoba, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,25]]},"reference":[{"key":"bibr1-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12339"},{"key":"bibr2-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1111\/head.13281"},{"key":"bibr3-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4152"},{"key":"bibr4-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.071"},{"key":"bibr5-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"bibr6-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000336"},{"key":"bibr7-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"bibr8-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2009.02.002"},{"key":"bibr9-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000219"},{"key":"bibr10-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0833-7"},{"key":"bibr11-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001231"},{"key":"bibr12-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420958384"},{"key":"bibr13-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"bibr14-03331024221084217","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1046\/j.1468-2982.1988.0801001.x","volume":"8","author":"ICHD-I","year":"1988","journal-title":"Cephalalgia"},{"key":"bibr15-03331024221084217","first-page":"S8","volume":"24","author":"ICHD-II","year":"2004","journal-title":"Cephalalgia"},{"key":"bibr16-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr17-03331024221084217","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr18-03331024221084217","unstructured":"Wells GA, Tugwell P, O\u2019Connell D, et\u00a0al. 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