{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:03:22Z","timestamp":1793340202354,"version":"4.5.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100013826","name":"Candys Foundation","doi-asserted-by":"publisher","award":["2015-146"],"award-info":[{"award-number":["2015-146"]}],"id":[{"id":"10.13039\/501100013826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","award":["R-276-2018-403-4"],"award-info":[{"award-number":["R-276-2018-403-4"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our objective was to assess optic nerve sheath diameter (a marker of elevated intracranial pressure) and optic disc elevation (a marker of papilledema) in pseudotumor cerebri syndrome using transorbital sonography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was a prospective case-control study. We included patients with new-onset pseudotumor cerebri syndrome and matched healthy controls. All had fundoscopy, lumbar puncture with opening pressure and transorbital sonography. Sonography was assessed by a blinded observer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We evaluated 45 patients and included 23 cases. We recruited 35 controls. Optic nerve sheath diameter was larger in pseudotumor cerebri syndrome compared to controls (6.3\u2009\u00b1\u20090.9\u2009mm versus 5.0\u2009\u00b1\u20090.5\u2009mm, p\u2009&lt;\u20090.001) and so was optic disc elevation (0.9\u2009\u00b1\u20090.4\u2009mm versus 0.4\u2009\u00b1\u20090.1\u2009mm, p\u2009&lt;\u20090.001). The optimal cut-off point for optic nerve sheath diameter was 6\u2009mm with a sensitivity of 74% for prediction of pseudotumor cerebri syndrome and 68% for prediction of elevated opening pressure. Specificity was 94%. The optimal cut-off point for optic disc elevation was 0.6\u2009mm. Sensitivity was 100% and specificity 83% for prediction of pseudotumor cerebri syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Optic disc elevation and optic nerve sheath diameter are increased in new-onset pseudotumor cerebri syndrome. Optic disc elevation achieved high specificity and excellent sensitivity for diagnosis of pseudotumor cerebri syndrome. Transorbital sonography (TOS) is a potential, non-invasive screening tool for pseudotumor cerebri syndrome in headache clinics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221094293","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T01:43:27Z","timestamp":1650937407000},"page":"1116-1126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Transorbital sonography: A non-invasive bedside screening tool for detection of pseudotumor cerebri syndrome"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-0712","authenticated-orcid":false,"given":"Johanne Juhl","family":"Korsb\u00e6k","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-8962","authenticated-orcid":false,"given":"Snorre Malm","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik W","family":"Schytz","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlasta","family":"Vukovic-Cvetkovic","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Arnberg","family":"Wibroe","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Hamann","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rigmor H","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"bibr1-03331024221094293","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a55f17"},{"key":"bibr2-03331024221094293","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317440"},{"key":"bibr3-03331024221094293","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002318"},{"key":"bibr4-03331024221094293","doi-asserted-by":"publisher","DOI":"10.1111\/aos.13748"},{"key":"bibr5-03331024221094293","first-page":"14","volume":"2012","author":"Raboel PH","year":"2012","journal-title":"Crit Care Res 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