{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:48:16Z","timestamp":1788994096141,"version":"build-2803163510"},"reference-count":28,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Perimenstrual migraine attacks in women with menstrual migraine is difficult to treat. This post-hoc analysis evaluated the efficacy of lasmiditan, a high affinity and selective 5-HT\n                      <jats:sub>1F<\/jats:sub>\n                      receptor agonist, for perimenstrual attacks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients from two randomized, double-blind, placebo-controlled clinical trials (MONONOFU and CENTURION) were instructed to treat an attack with a single dose of study medication within four hours of pain onset. After dosing, the proportion of patients who achieved freedom from migraine-related head pain, most bothersome symptom, and disability was reported at baseline up to 48 hours after dose and pooled data were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 303 patients (MONONOFU N\u2009=\u200978; CENTURION N\u2009=\u2009225) treated perimenstrual migraine attacks with lasmiditan 50\u2009mg (N\u2009=\u200924), 100\u2009mg (N\u2009=\u200990), 200\u2009mg (N\u2009=\u2009110), and placebo (N\u2009=\u200979). More patients achieved migraine-related head pain freedom with lasmiditan 200\u2009mg versus placebo at all time points assessed. At 2 hours, 33.6% of patients in the 200-mg group (p\u2009&lt;\u20090.001), and 16.7% of patients in the 100-mg (p\u2009=\u20090.11) and 50-mg (p\u2009=\u20090.19) groups were pain free, compared with 7.6% in the placebo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lasmiditan treatment of perimenstrual migraine attacks was associated with freedom from migraine-related head pain at two hours, early onset of efficacy, and sustained efficacy. Clinical Trial registration: NCT03962738 and NCT03670810<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221118929","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T03:35:50Z","timestamp":1660793750000},"page":"1467-1475","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of lasmiditan for the acute treatment of perimenstrual migraine"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4116-9828","authenticated-orcid":false,"given":"E Anne","family":"MacGregor","sequence":"first","affiliation":[{"name":"Centre for Reproductive Medicine, St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Komori","sequence":"additional","affiliation":[{"name":"Eli Lilly KK, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Henry","family":"Krege","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Baygani","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice","family":"Vincent","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, IN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisaka","family":"Igarashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Headache Care Unit, Fujitsu Clinic, Kawasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"bibr1-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"bibr2-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409355601"},{"key":"bibr3-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr4-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1414182"},{"key":"bibr5-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-005-0156-3"},{"key":"bibr6-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00295.x"},{"key":"bibr7-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04027.x"},{"key":"bibr8-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01313.x"},{"key":"bibr9-03331024221118929","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1526-4610.2008.01310.x","volume":"48","author":"Martin V","year":"2008","journal-title":"Headache"},{"key":"bibr10-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01076.x"},{"key":"bibr11-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01093.x"},{"key":"bibr12-03331024221118929","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200620120-00005"},{"key":"bibr13-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.01019.x"},{"key":"bibr14-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133134.68143.2E"},{"key":"bibr15-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2002.02214.x"},{"key":"bibr16-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.10.1517"},{"key":"bibr17-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30482-8"},{"key":"bibr18-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1177\/0333102421989232"},{"key":"bibr19-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz134"},{"key":"bibr20-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006641"},{"key":"bibr21-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01088-4"},{"key":"bibr22-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/head.14122"},{"key":"bibr23-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2001.01156.x"},{"key":"bibr24-03331024221118929","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.suppl_1.S20"},{"key":"bibr25-03331024221118929","unstructured":"Clinical global impressions. 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