{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:11:41Z","timestamp":1782270701461,"version":"3.54.5"},"reference-count":49,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the clinical profiles between male and female cluster headache patients from a large cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This hospital-based study enrolled patients diagnosed with cluster headache between 1997 to 2021. Participants completed structured questionnaires collecting information on demographics, clinical profiles, and quality of life. Treatment regimens and effectiveness were determined through medical chart review. All variables were compared between the sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 798 patients (M\/F:659\/139) were enrolled. The male-to-female ratio was 4.7:1 for the full study period, but it declined from 5.2:1 to 4.3:1 for patients enrolled before and after 2010, respectively. The frequencies of chronic cluster headache (M:1.2%, F:1.4%) and aura (M:0.3%, F:0.7%) were low but similar between the sexes. Most headache features showed no difference between men and women. Female patients had significantly longer attack duration, shorter inter-bout duration, higher frequencies for eyelid edema, nausea and vomiting and lower frequencies for conjunctival injection and pacing. Sex difference did not influence headache-associated disability, anxiety, or depression, but poor sleep quality was significantly more common in women. Among menstruating women, 22\/122 (18.0%) reported worsening headaches during menses. The effectiveness of treatment was similar between the sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite a decline of male-to-female ratio in the past two decades, most clinical profiles were similar between the sexes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221120054","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T01:18:35Z","timestamp":1661390315000},"page":"1532-1542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Sex-related differences in cluster headache: A hospital-based study in Taiwan"],"prefix":"10.1177","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9093-7045","authenticated-orcid":false,"given":"Yi-Chia","family":"Liaw","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-3432","authenticated-orcid":false,"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ta","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Department of Neurology, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0952-9608","authenticated-orcid":false,"given":"Jr-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-6555","authenticated-orcid":false,"given":"Kuan-Lin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ling","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-5358","authenticated-orcid":false,"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"bibr1-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01592.x"},{"key":"bibr2-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr3-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.6"},{"key":"bibr4-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-001-0011-4"},{"key":"bibr5-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1305309.x"},{"key":"bibr6-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0922-7"},{"key":"bibr7-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420923646"},{"key":"bibr8-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/head.13637"},{"key":"bibr9-03331024221120054","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.3.502"},{"key":"bibr10-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-27"},{"key":"bibr11-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410391486"},{"key":"bibr12-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2003.00721.x"},{"key":"bibr13-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.5.613"},{"key":"bibr14-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.3.354"},{"key":"bibr15-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003715"},{"key":"bibr16-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.03.006"},{"key":"bibr17-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1080\/17571472.2010.11493315"},{"key":"bibr18-03331024221120054","unstructured":"Ministry of Health and Welfare. Body height, body weight and BMI (\u8eab\u9ad8\u3001\u9ad4\u91cd\u3001\u8eab\u9ad4\u8cea\u91cf\u6307\u6578), https:\/\/dep.mohw.gov.tw\/dos\/cp-5339-59467-113.html (accessed 7 May 2022, published 15 June 2022)."},{"key":"bibr19-03331024221120054","unstructured":"Administrative Yuan of Taiwan. The drinking rate in Taiwanese general population, \nhttps:\/\/www.gender.ey.gov.tw\/gecdb\/Stat_Statistics_DetailData.aspx?sn=GW1JgaxFwb22%24EJmHuebGg%40%40&d=194q2o4!otzoYO!8OAMYew%40%40\n (accessed 1 May 2022, published 15 December 2020)."},{"key":"bibr20-03331024221120054","unstructured":"Health Promotion Administration MoHaW. Adult Smoking Behavior Survey (ASBS), https:\/\/www.gender.ey.gov.tw\/gecdb\/Stat_Statistics_DetailData.aspx?sn=ORVNSDIGVFTYgkN!7bdIyA%40%40&d=m9ww9odNZAz2Rc5Ooj%24wIQ%40%40 (2019, accessed 20 January 2022)."},{"key":"bibr21-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"bibr22-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.suppl_1.S20"},{"key":"bibr23-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"bibr24-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026119331193"},{"key":"bibr25-03331024221120054","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15112457"},{"key":"bibr26-03331024221120054","unstructured":"Department of Household Registration MOI, Taiwan. The demographic data in each county classified by gender and age (\u7e23\u5e02\u4eba\u53e3\u6309\u6027\u5225\u53ca\u4e94\u9f61\u7d44), https:\/\/www.ris.gov.tw\/app\/portal\/346 (accessed 10 January 2022, published 31 December 2021)."},{"key":"bibr27-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1988.0801037.x"},{"key":"bibr28-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1998.1803138.x"},{"key":"bibr29-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3709588.x"},{"key":"bibr30-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-007-0009-7"},{"key":"bibr31-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418784751"},{"key":"bibr32-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000680"},{"key":"bibr33-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1983.0301021.x"},{"key":"bibr34-03331024221120054","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.139987"},{"key":"bibr35-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12101"},{"key":"bibr36-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221155"},{"key":"bibr37-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/head.12241"},{"key":"bibr38-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1123"},{"key":"bibr39-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419863030"},{"key":"bibr40-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-012-0248-0"},{"key":"bibr41-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417731773"},{"key":"bibr42-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224407"},{"key":"bibr43-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0683-0"},{"key":"bibr44-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.081158"},{"key":"bibr45-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413507637"},{"key":"bibr46-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1992.hed3206292.x"},{"key":"bibr47-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412469738"},{"key":"bibr48-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00534.x"},{"key":"bibr49-03331024221120054","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.02028.x"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024221120054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024221120054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024221120054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:40Z","timestamp":1777387780000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/03331024221120054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,24]]},"references-count":49,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1177\/03331024221120054"],"URL":"https:\/\/doi.org\/10.1177\/03331024221120054","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,24]]}}}