{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:08:24Z","timestamp":1789474104334,"version":"build-2803163510"},"reference-count":38,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It has been suggested that patients with migraine have a higher risk of stroke. Despite considerable research on this topic in younger populations, a clear answer is still lacking for older individuals. We studied the association between migraine and the risk of stroke in a middle-aged and elderly population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within the ongoing prospective population-based Rotterdam Study, the presence of migraine was assessed using a validated questionnaire in a structured interview between 2006 and 2011, which formed the baseline. The association between migraine and the risk of stroke was analyzed using Cox proportional-hazards models with adjustments for age, sex, and cardiometabolic risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 6925 (mean age 65.7\u2009\u00b1\u200911.3 years, 57.8% females) stroke-free participants were included. At baseline, 1030 (14.9%) participants had lifetime history of migraine. During a median follow-up of 6.2 years, 195 participants developed a stroke (163 ischemic stroke). Analyzing the association between migraine and stroke, we found a hazard ratio of 1.44 with a 95% confidence interval of 0.96\u20132.15. The results were similar for the ischemic stroke (HR 1.50, CI: 0.97\u20132.32).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggested an association between migraine and the risk of stroke in a middle-aged and elderly population, but this was not statistically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221132008","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T13:41:31Z","timestamp":1673271691000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Migraine and the risk of stroke in a middle-aged and elderly population: A prospective cohort study"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-916X","authenticated-orcid":false,"given":"Cevdet","family":"Acarsoy","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Fani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Al-Hassany","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P","family":"Berghout","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4998-9609","authenticated-orcid":false,"given":"Peter J","family":"Koudstaal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Maassen Van Den Brink","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Kamran","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bos","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"},{"name":"Department of Radiology & Nuclear Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"bibr1-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3914"},{"key":"bibr2-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-022-06074-z"},{"key":"bibr3-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01338-z"},{"key":"bibr4-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13060"},{"key":"bibr5-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1111\/head.13468"},{"key":"bibr6-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027701"},{"key":"bibr7-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000110312.36809.7F"},{"key":"bibr8-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.8.795"},{"key":"bibr9-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001854"},{"key":"bibr10-03331024221132008","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-020-00640-5"},{"key":"bibr11-03331024221132008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1468-2982.2003.00824.x","volume":"24","author":"Headache 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