{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:39:02Z","timestamp":1791459542300,"version":"4.3.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Calcitonin gene-related peptide-targeted drugs have proven safe and effective for migraine prevention in large randomized-controlled, double-blind trials with an average duration of six months. Open-label studies may provide additional information on the long-term safety and efficacy of these substances.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed for open-label trials with calcitonin gene-related peptide(-receptor) monoclonal antibodies and calcitonin gene-related peptide-receptor antagonists. We summarized and critically analyzed the literature in a narrative way.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 13 open-label trials were included in this review (n\u2009=\u20094 for erenumab, n\u2009=\u20094 for galcanezumab, n\u2009=\u20093 for fremanezumab, n\u2009=\u20091 for eptinezumab, n\u2009=\u20091 for atogepant). Open-label trial duration ranged between 12 and 264 weeks. No safety concerns emerged, and the adverse events profile was similar to the double-blind study phase. Discontinuation rates were generally low with &gt;75% of patients remaining in the trials after one year. Efficacy data showed a sustained reduction of migraine frequency throughout the trials, along with a lasting improvement in quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The open-label study program for calcitonin gene-related peptide-targeted migraine preventives confirms the favorable safety and efficacy profile of these drugs over time. Treatment adherence appears higher than with previous unspecific migraine preventives. Real-world data and post-marketing surveillance studies may corroborate and complement open-label results.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221137091","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T01:06:48Z","timestamp":1675127208000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Open-label trials for CGRP-targeted drugs in migraine prevention: A narrative review"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9758-1494","authenticated-orcid":false,"given":"Bianca","family":"Raffaelli","sequence":"first","affiliation":[{"name":"Department of Neurology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Clinician Scientist Program, Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-4948","authenticated-orcid":false,"given":"Roberto","family":"De Icco","sequence":"additional","affiliation":[{"name":"Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy"},{"name":"Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Corrado","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Terhart","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Ailani","sequence":"additional","affiliation":[{"name":"MedStar Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"bibr1-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330109"},{"key":"bibr2-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0003-1"},{"key":"bibr3-03331024221137091","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730020-00001"},{"key":"bibr4-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14715"},{"key":"bibr5-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00506.x"},{"key":"bibr6-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2008.01299.x"},{"key":"bibr7-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0807-1"},{"key":"bibr8-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004391"},{"key":"bibr9-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419854082"},{"key":"bibr10-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32534-0"},{"key":"bibr11-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012029"},{"key":"bibr12-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327480"},{"key":"bibr13-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1111\/head.14096"},{"key":"bibr14-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30083-2"},{"key":"bibr15-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420912726"},{"key":"bibr16-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420973994"},{"key":"bibr17-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419888222"},{"key":"bibr18-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008743"},{"key":"bibr19-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4678"},{"key":"bibr20-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1193-2"},{"key":"bibr21-03331024221137091","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-020-02632-0"},{"key":"bibr22-03331024221137091","author":"Pozo-Rosich 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