{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T14:43:32Z","timestamp":1793889812342,"version":"4.8.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This post-hoc analysis from three phase 3 treatment trials of rimegepant 75\u2009mg \u2014 an oral small molecule calcitonin gene-related peptide receptor antagonist for acute and preventive treatment of migraine \u2014 assessed efficacy in adults with migraine based on triptan treatment experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were assigned to one of four groups based on triptan treatment experience: insufficient response (e.g. lack of efficacy and\/or poor tolerability) to 1 triptan, insufficient response to \u22652 triptans, current triptan users, and triptan-na\u00efve participants. The co-primary efficacy endpoints were pain freedom and most bothersome symptom freedom at two hours postdose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the three trials (N\u2009=\u20093507; rimegepant n\u2009=\u20091749, placebo n\u2009=\u20091758), 1235 (35.2%) participants had a history of insufficient response to 1 triptan (n\u2009=\u2009910 [25.9%]) or \u22652 triptans (n\u2009=\u2009325 [9.3%]), and 2272 (64.8%) had no history of insufficient response to triptans (current use\u2009=\u2009595 [17.0%], na\u00efve\u2009=\u20091677 [47.8%]). Rimegepant was effective on the co-primary endpoints in all subgroups ( p\u2009\u2264\u20090.013), except for freedom from the most bothersome symptom in the triptan-na\u00efve group ( p\u2009=\u20090.06). No differences on co-primary endpoints were found in pairwise comparisons of rimegepant-treated participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Rimegepant was effective for the acute treatment of migraine in adults with a history of insufficient response to 1 or \u22652 triptans and in current triptan users. Efficacy on co-primary endpoints did not differ based on the number of insufficient triptan responses. Trial registration: Clinicaltrials.gov: NCT03235479, NCT03237845, NCT03461757<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024221141686","type":"journal-article","created":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T03:20:52Z","timestamp":1675567252000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Efficacy of rimegepant for the acute treatment of migraine based on triptan treatment experience: Pooled results from three phase 3 randomized clinical trials"],"prefix":"10.1177","volume":"43","author":[{"given":"Richard B","family":"Lipton","sequence":"first","affiliation":[{"name":"Departments of Neurology, Epidemiology and Population Health, and Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY, 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