{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:13:04Z","timestamp":1777489984812,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A new migraine prevention, CGRP monoclonal antibodies (mAbs), is injectable on a monthly or quarterly basis. In clinical practice, some patients reported that drug effectiveness does not last until the upcoming scheduled injection, a so-called \u201cwearing-off\u201d effect. We aimed to evaluate the wearing-off effect of the CGRP mAbs for migraine prevention in patients with different monthly migraine days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a literature search for studies that reported migraine frequency after CGRP monoclonal antibody administration from MEDLINE, SCOPUS, Web of Science, and Cochrane Database from inception through February 2022. A meta-analysis, random-effects model was applied to assess the difference in migraine frequency between early and later weeks after medication to assess the presence of a wearing-off effect. Risk ratio was calculated to report the pooled treatment effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four studies were entered for the analysis, comprising 2409 patients in randomized controlled trials. There was no association between CGRP mAbs and wearing-off effect in patients with galcanezumab with a pooled risk ratio of 1.29 (95% CI 0.73 to 2.28) compared to placebo group. However, there was an association between galcanezumab and wearing-off effect in patients with chronic migraine with a pooled risk ratio of 1.91 (95% CI 1.11 to 3.28) compared to placebo group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this meta-analysis, there was a wearing-off efficacy of galcanezumab but only in a small percentage of patients with chronic migraine in randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231161261","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T05:10:16Z","timestamp":1678943416000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["\u201cWearing-off\u201d efficacy of CGRP monoclonal antibodies for migraine prevention: A meta-analysis of randomized controlled trials"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3119-2610","authenticated-orcid":false,"given":"Thanin","family":"Asawavichienjinda","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-6534","authenticated-orcid":false,"given":"Seelwan","family":"Sathitratanacheewin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronpichai","family":"Chokesuwattanaskul","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"bibr1-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410381145"},{"key":"bibr2-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1111\/head.13459"},{"key":"bibr3-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr4-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01222-w"},{"key":"bibr5-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1111\/head.14153"},{"key":"bibr6-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-017-0463-4"},{"key":"bibr7-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0955-y"},{"key":"bibr8-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419840780"},{"key":"bibr9-03331024231161261","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00363"},{"key":"bibr10-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20458"},{"key":"bibr11-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417724150"},{"key":"bibr12-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1111\/head.13713"},{"key":"bibr13-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1111\/head.13638"},{"key":"bibr14-03331024231161261","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny282"},{"key":"bibr15-03331024231161261","first-page":"56","volume":"61","author":"Garcia-Ayala 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