{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:13:34Z","timestamp":1777490014286,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The connection between migraine aura and headache is poorly understood. Some patients experience migraine aura without headache, and patients with migraine aura with headache commonly experience milder headaches with age. The distance between the cerebral cortex and the overlying dura mater has been hypothesized to influence development of headache following aura. We tested this hypothesis by comparing approximated distances between visual cortical areas and overlying dura mater between female patients with migraine aura without headache and female patients with migraine aura with headache.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twelve cases with migraine aura without headache and 45 age-matched controls with migraine aura with headache underwent 3.0 T MRI. We calculated average distances between the occipital lobes, between the calcarine sulci, and between the skull and visual areas V1, V2 and V3a. We also measured volumes of corticospinal fluid between the occipital lobes, between the calcarine sulci, and overlying visual areas V2 and V3a. We investigated the relationship between headache status, distances and corticospinal fluid volumes using conditional logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Distances between the occipital lobes, calcarine sulci and between the skull and V1, V2 and V3a did not differ between patients with migraine aura with headache and patients with migraine aura without headache. We found no differences in corticospinal fluid volumes between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found no indication for a connection between visual migraine aura and headache based on cortico-cortical, cortex-to-skull distances, or corticospinal fluid volumes overlying visual cortical areas. Longitudinal studies with imaging sequences optimized for measuring the cortico-dural distance and a larger sample of patients are needed to further investigate the hypothesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231170541","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T04:57:44Z","timestamp":1687150664000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigations of the subarachnoid space as a potential link between aura and headache in migraine: A case-control MRI study"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6079-3263","authenticated-orcid":false,"given":"Andreas Vinther","family":"Thomsen","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oula","family":"Puonti","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gaist","sequence":"additional","affiliation":[{"name":"Research Unit for Neurology, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten Ohm","family":"Kyvik","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark"},{"name":"The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark"},{"name":"Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer","family":"Madsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Thielscher","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hartwig Roman","family":"Siebner","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Neurology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hougaard","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,19]]},"reference":[{"key":"bibr1-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.2.355"},{"key":"bibr2-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"bibr3-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00260.x"},{"key":"bibr4-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0511-10.2010"},{"key":"bibr5-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01647.x"},{"key":"bibr6-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25731"},{"key":"bibr7-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000225186.76323.69"},{"key":"bibr8-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww099"},{"key":"bibr9-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx382"},{"key":"bibr10-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102361"},{"key":"bibr11-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1375\/twin.9.6.763"},{"key":"bibr12-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000151858.15482.66"},{"key":"bibr13-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr14-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21629"},{"key":"bibr15-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"bibr16-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117044"},{"key":"bibr17-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30185-1"},{"key":"bibr18-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13413"},{"key":"bibr19-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1940.01210040002001"},{"key":"bibr20-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01646.x"},{"key":"bibr21-03331024231170541","doi-asserted-by":"publisher","DOI":"10.1177\/0333102411422383"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231170541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024231170541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231170541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:45:53Z","timestamp":1777387553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231170541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/03331024231170541"],"URL":"https:\/\/doi.org\/10.1177\/03331024231170541","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"article-number":"03331024231170541"}}