{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:13:33Z","timestamp":1777490013173,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"The RCT was funded by the German Migraine and Headache Society (DMKG) and by internal funds (Department of Psychology, Johannes Gutenberg University of Mainz)."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While growing evidence suggests the efficacy of various behavioral approaches to the preventive treatment of migraine, it remains largely unclear which behavioral interventions are indicated for which type of patient. This exploratory study aimed to identify moderators for the outcome between migraine-specific cognitive-behavioral therapy and relaxation training.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this secondary analysis of an open-label randomized controlled trial, the data of N\u2009\u2009=\u2009\u200977 adults (completer sample) with migraine (mean age\u2009=\u200947.4, SD\u2009=\u200912.2, 88% female), who were allocated to either migraine-specific cognitive-behavioral therapy or relaxation training, was examined. Outcome was the frequency of headache days at the 12-month follow-up. We analyzed baseline demographic or clinical characteristics and headache-specific variables (disability, emotional distress, trigger sensitivity and avoidance, pain acceptance, self-efficacy) as candidate moderators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher headache-related disability (assessed via the Headache Impact Test, HIT-6, B\u2009=\u2009\u20130.41 [95% CI: \u20130.85 to \u20130.10], p\u2009=\u2009.047), higher anxiety (assessed via the subscale Anxiety of the Depression, Anxiety and Stress scales, DASS-A, B\u2009=\u2009\u20130.66 [95% CI: \u20131.27 to \u20130.02], p\u2009=\u2009.056), and the presence of a comorbid mental disorder ( B\u2009=\u2009\u20134.98, [95% CI: \u20139.42 to \u20130.29], p\u2009=\u2009.053), moderated the outcome in favor of migraine-specific cognitive-behavioral therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings contribute to an individualized treatment selection and suggest that preference for complex behavioral treatment (migraine-specific cognitive-behavioral therapy) should be given to patients with high headache-related disability, increased anxiety, or a comorbid mental disorder. Study Registration: Original study registered in the German Clinical Trials Register ( https:\/\/drks.de\/search\/de ; DRKS-ID: DRKS00011111).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231178237","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T02:45:03Z","timestamp":1686278703000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Behavioral treatment for migraine prophylaxis in adults: Moderator analysis of a randomized controlled trial"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-6128","authenticated-orcid":false,"given":"Timo","family":"Klan","sequence":"first","affiliation":[{"name":"Department of Psychology, Johannes Gutenberg University of Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charly","family":"Gaul","sequence":"additional","affiliation":[{"name":"Headache Center Frankfurt, Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Liesering-Latta","sequence":"additional","affiliation":[{"name":"DRK Pain Center Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Witth\u00f6ft","sequence":"additional","affiliation":[{"name":"Department of Psychology, Johannes Gutenberg University of Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Severin","family":"Hennemann","sequence":"additional","affiliation":[{"name":"Department of Psychology, Johannes Gutenberg University of Mainz, Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"bibr1-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-022-01023-z"},{"key":"bibr2-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01369-6"},{"key":"bibr3-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.08.014"},{"key":"bibr4-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417727535"},{"key":"bibr5-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000309"},{"key":"bibr6-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0533-5"},{"key":"bibr7-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2017.1377611"},{"key":"bibr8-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1715212"},{"key":"bibr9-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-010-0112-z"},{"key":"bibr10-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2005.05103.x"},{"key":"bibr11-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1111\/head.14290"},{"key":"bibr12-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s42451-023-00550-2"},{"key":"bibr13-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1111\/head.12966"},{"key":"bibr14-03331024231178237","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.852616"},{"key":"bibr15-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr16-03331024231178237","volume-title":"Diagnostische Kriterien DSM-5.","author":"Falkai P","year":"2015"},{"key":"bibr17-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1026\/02851-000"},{"key":"bibr18-03331024231178237","unstructured":"Campbell JK, Penzien DB, Wall EM. Evidence-Based Guidelines for Migraine Headache: Behavioral and Physical Treatments: American Academy of Neurology, https:\/\/hpmaine.com\/images\/PDFs\/aan-guidelines.pdf. (2000, accessed 12 November 2018)."},{"key":"bibr19-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0630-0"},{"key":"bibr20-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420941839"},{"key":"bibr21-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418758283"},{"key":"bibr22-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s001150050475"},{"key":"bibr23-03331024231178237","first-page":"963","volume":"12","author":"Kosinski M","year":"2003","journal-title":"QoLRes"},{"key":"bibr24-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/BF02530415"},{"key":"bibr25-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1111\/head.12564"},{"key":"bibr26-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-015-0019-z"},{"key":"bibr27-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1159\/000501218"},{"key":"bibr28-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1007\/s00482-006-0508-1"},{"key":"bibr29-03331024231178237","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes AF.","year":"2018"},{"key":"bibr30-03331024231178237","first-page":"21","volume":"6","author":"Dahiru T.","year":"2008","journal-title":"Ann Ib Postgrad Med"},{"key":"bibr31-03331024231178237","first-page":"16","volume-title":"Bergin and Garfield's Handbook of Psychotherapy and Behavior Change","author":"Kendall PC","year":"2004"},{"key":"bibr32-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2018.42"},{"key":"bibr33-03331024231178237","doi-asserted-by":"publisher","DOI":"10.1111\/head.14272"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231178237","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024231178237","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231178237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:45:53Z","timestamp":1777387553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231178237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1177\/03331024231178237"],"URL":"https:\/\/doi.org\/10.1177\/03331024231178237","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]},"article-number":"03331024231178237"}}