{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:38:19Z","timestamp":1792827499245,"version":"4.5.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002742","name":"Banaras Hindu University","doi-asserted-by":"publisher","award":["IOE grant number 42872"],"award-info":[{"award-number":["IOE grant number 42872"]}],"id":[{"id":"10.13039\/501100002742","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Migraine is a common headache syndrome associated with various other comorbidities. Thyroid replacement in migraine patients with hypothyroidism improves headaches; however, thyroid hormone replacement in subclinical hypothyroidism is debatable, and its efficacy is not known.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective and methodology<\/jats:title>\n                    <jats:p>This prospective, single-centre, quasi-randomised interventional study was conducted on patients visiting the General Medicine and Neurology outpatient department at a tertiary centre to look at the efficacy of thyroxine in subclinical hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We assessed 87 patients for analysis; no patients were lost to follow-up. There was a decrease in all parameters evaluated (headache frequency, severity, duration, MIDAS score, MIDAS grade) at three months of follow-up in the treatment group compared to placebo group. There was a significant decrease in headache frequency and severity in the levothyroxine group compared to the placebo group at three months of follow-up. Also, the follow-up MIDAS score (mean\u2009\u00b1\u2009SD: 6.30\u2009\u00b1\u20092.455 scores vs. 8.45\u2009\u00b1\u20095.757 scores) was significantly decreased by treatment at three months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment of subclinical hypothyroidism effectively reduces migraine headaches, and it is logical to check thyroid function status in patients presenting with migraine headaches. However, a larger randomised controlled trial is required to prove the efficacy of levothyroxine in migraine with subclinical hypothyroidism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231182684","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T19:33:36Z","timestamp":1696620816000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The effect of low dose thyroid replacement therapy in patients with episodic migraine and subclinical hypothyroidism: A randomised placebo-controlled trial"],"prefix":"10.1177","volume":"43","author":[{"given":"Priya","family":"Dev","sequence":"first","affiliation":[{"name":"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.T.","family":"Favas","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishab","family":"Jaiswal","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareena","family":"Cyriac","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Nath","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2019.06.001"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000169750.52406.a2"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418769917"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-14-S1-P138"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416658714"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.1998.1810687.x"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9052"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.4.526"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/20009666.2017.1422672"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2014.29.1.20"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12943"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0121"},{"key":"e_1_3_4_16_2","first-page":"23","article-title":"Efficacy of levothyroxine in migraine headaches in children with subclinical hypothyroidism","volume":"6","author":"Mirouliaei M","year":"2012","unstructured":"Mirouliaei M, Fallah R, Bashardoost Net\u00a0al. Efficacy of levothyroxine in migraine headaches in children with subclinical hypothyroidism. Iran J Child Neurol 2012; 6: 23\u201326.","journal-title":"Iran J Child Neurol"},{"key":"e_1_3_4_17_2","first-page":"257","article-title":"Association of hypothyroidism in patients with migraine and tension-type headache disorders in Kashmir, North India","volume":"20","author":"Khan HB","year":"2015","unstructured":"Khan HB, Shah PA, Bhat MHet\u00a0al. Association of hypothyroidism in patients with migraine and tension-type headache disorders in Kashmir, North India. Neurology Asia 2015; 20: 257\u2013256.","journal-title":"Neurology Asia"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0205"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1231"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56010040"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000356507"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018815616543"},{"key":"e_1_3_4_23_2","first-page":"116","article-title":"Efficacy of levothyroxine in migraine patients with subclinical hypothyroidism","volume":"24","author":"Bougea A","year":"2017","unstructured":"Bougea A, Spantideas N, Anagnostou Eet\u00a0al. Efficacy of levothyroxine in migraine patients with subclinical hypothyroidism. 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