{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:18:18Z","timestamp":1782933498980,"version":"3.54.5"},"reference-count":44,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","award":["E-23831-03"],"award-info":[{"award-number":["E-23831-03"]}],"id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009910","name":"Hartmann Fonden","doi-asserted-by":"publisher","award":["A37853"],"award-info":[{"award-number":["A37853"]}],"id":[{"id":"10.13039\/501100009910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R373-2021"],"award-info":[{"award-number":["R373-2021"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate whether levcromakalim (a K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel opener) induces migraine-like headache in people with persistent post-traumatic headache who had no known history of migraine.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomized, double-blind, placebo-controlled, 2-way crossover trial, participants were randomly assigned to receive a 20-minute continuous intravenous infusion of levcromakalim (50\u2009\u00b5g\/mL) or placebo (isotonic saline) on two separate experimental days with a 1-week wash-out period in between. The primary endpoint was the difference in incidence of migraine-like headache between levcromakalim and placebo during a 12-hour observational period after infusion start. The secondary endpoint was the difference in area under the curve for baseline-corrected median headache intensity scores between levcromakalim and placebo during the 12-hour observational period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 21 participants with persistent post-traumatic headache were randomized and completed the trial. During the 12-hour observational period, 12 (57%) of 21 participants reported experiencing migraine-like headache following the levcromakalim infusion, compared with three after placebo ( P\u2009=\u20090.013). Moreover, the baseline-corrected median headache intensity scores were higher following the levcromakalim infusion than after placebo ( P\u2009=\u20090.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that K\n                      <jats:sub>ATP<\/jats:sub>\n                      channels play an important role in the pathogenesis of migraine-like headache in people with persistent post-traumatic headache. This implies that K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel blockers might represent a promising avenue for drug development. Further research is warranted to explore the potential therapeutic benefits of K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel blockers in managing post-traumatic headache. Trial Registration: ClinicalTrials.gov Identifier: NCT05243953\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231210930","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T15:09:53Z","timestamp":1698937793000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache"],"prefix":"10.1177","volume":"43","author":[{"given":"Haidar M.","family":"Al-Khazali","sequence":"first","affiliation":[{"name":"Harvard Medical School, MA, USA"},{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"},{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune H.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Harvard Medical School, MA, USA"},{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"},{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Dodick","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basit Ali","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Burstein","sequence":"additional","affiliation":[{"name":"Harvard Medical School, MA, USA"},{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-727X","authenticated-orcid":false,"given":"H\u00e5kan","family":"Ashina","sequence":"additional","affiliation":[{"name":"Harvard Medical School, MA, USA"},{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"},{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Brain and Spinal Cord Injury, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"bibr1-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00094-6"},{"key":"bibr2-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0243-8"},{"key":"bibr3-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1051-7"},{"key":"bibr4-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"bibr5-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32162-0"},{"key":"bibr6-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz199"},{"key":"bibr7-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab136"},{"key":"bibr8-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420909865"},{"key":"bibr9-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420981666"},{"key":"bibr10-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25915"},{"key":"bibr11-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad367"},{"key":"bibr12-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90511-N"},{"key":"bibr13-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9851-0"},{"key":"bibr14-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01569-2"},{"key":"bibr15-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00059.2021"},{"key":"bibr16-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"bibr17-03331024231210930","first-page":"1","volume-title":"Cephalalgia","volume":"38","year":"2018","edition":"3"},{"key":"bibr18-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"bibr19-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419888490"},{"key":"bibr20-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-020-00911-6"},{"key":"bibr21-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-014-0301-z"},{"key":"bibr22-03331024231210930","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420925513"},{"key":"bibr23-03331024231210930","author":"Al-Khazali 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