{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:47:51Z","timestamp":1788526071607,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["1014333"],"award-info":[{"award-number":["1014333"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R93-A8392"],"award-info":[{"award-number":["R93-A8392"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fabrikant Vilhelm Pedersen and Hustrus legat"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have applied resting-state functional MRI to examine whether functional brain connectivity is altered in migraine with aura patients. These studies had multiple limitations, including small sample sizes, and reported conflicting results. Here, we performed a large, cross-sectional brain imaging study to reproduce previous findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited women aged 30\u201360 years from the nationwide Danish Twin Registry. Resting-state functional MRI of women with migraine with aura, their co-twins, and unrelated migraine-free twins was performed at a single centre. We carried out an extensive series of brain connectivity data analyses. Patients were compared to migraine-free controls and to co-twins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Comparisons were based on data from 160 patients, 30 co-twins, and 136 controls. Patients were similar to controls with regard to age, and several lifestyle characteristics. We replicated clear effects of age on resting-state networks. In contrast, we failed to detect any differences, and to replicate previously reported differences, in functional connectivity between migraine patients with aura and non-migraine controls or their co-twins in any of the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the large sample size and the unbiased population-based design of our study, we conclude that women with migraine with aura have normal resting-state brain connectivity outside of migraine attacks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231212574","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T08:30:40Z","timestamp":1699691440000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Lack of reproducibility of resting-state functional MRI findings in migraine with aura"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-7426","authenticated-orcid":false,"given":"Anders","family":"Hougaard","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Neurology, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gaist","sequence":"additional","affiliation":[{"name":"Research Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Garde","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Iversen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla G.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Radiology, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten O.","family":"Kyvik","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Environmental Health, University of Copenhagen, Copenhagen, Denmark"},{"name":"The Danish Twin Registry, Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, Odense, Denmark"},{"name":"Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet Glostrup, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig R.","family":"Siebner","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Neurology, Copenhagen University Hospital \u2013 Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer H.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital \u2013 Amager and Hvidovre, Hvidovre, Denmark"},{"name":"Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,11,11]]},"reference":[{"key":"bibr1-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"bibr2-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2014"},{"key":"bibr3-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132388"},{"key":"bibr4-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.191"},{"key":"bibr5-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415583144"},{"key":"bibr6-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1111\/head.12587"},{"key":"bibr7-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415584360"},{"key":"bibr8-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0782-6"},{"key":"bibr9-03331024231212574","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01039"},{"key":"bibr10-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001770"},{"key":"bibr11-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01473-1"},{"key":"bibr12-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15061"},{"key":"bibr13-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12636"},{"key":"bibr14-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1375\/twin.9.6.763"},{"key":"bibr15-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000151858.15482.66"},{"key":"bibr16-03331024231212574","first-page":"629","volume-title":"Cephalalgia","volume":"33","year":"2013","edition":"3"},{"key":"bibr17-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww099"},{"key":"bibr18-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.07.051"},{"key":"bibr19-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.03.012"},{"key":"bibr20-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"bibr21-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1162\/neco.1995.7.6.1129"},{"key":"bibr22-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0516"},{"key":"bibr23-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"bibr24-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx382"},{"key":"bibr25-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.12.034"},{"key":"bibr26-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.06.058"},{"key":"bibr27-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23548"},{"key":"bibr28-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.081"},{"key":"bibr29-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4135"},{"key":"bibr30-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"bibr31-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"bibr32-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22744"},{"key":"bibr33-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00411.2021"},{"key":"bibr34-03331024231212574","volume":"5","author":"Allen E","journal-title":"Front Systems Neurosci"},{"key":"bibr35-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117126"},{"key":"bibr36-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(91)90147-2"},{"key":"bibr37-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.20668"},{"key":"bibr38-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"bibr39-03331024231212574","volume":"10","author":"Specht K.","journal-title":"Front Psychiatry"},{"key":"bibr40-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.02.001"},{"key":"bibr41-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.12.001"},{"key":"bibr42-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116073"},{"key":"bibr43-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12396"},{"key":"bibr44-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2022.119414"},{"key":"bibr45-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2923274"},{"key":"bibr46-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113257"},{"key":"bibr47-03331024231212574","first-page":"1","volume-title":"Cephalalgia","volume":"38","year":"2018","edition":"3"},{"key":"bibr48-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1604239.x"},{"key":"bibr49-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1047-3"},{"key":"bibr50-03331024231212574","author":"Jia X-Z","year":"2018","journal-title":"BioRxiv"},{"key":"bibr51-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.074"},{"key":"bibr52-03331024231212574","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-016-0716-8"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231212574","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024231212574","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231212574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:45:26Z","timestamp":1777387526000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231212574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1177\/03331024231212574"],"URL":"https:\/\/doi.org\/10.1177\/03331024231212574","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]},"article-number":"03331024231212574"}}