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The present perspective summarizes the evidence linking CGRP to the migraine aura and proposes a model by which targeting the CGRP-pathways and, thus, inhibition the interaction between C- and A\u03b4-trigeminal fibers might reverse a possible high cortical glutamate level leading to a reduced number of migraine auras.<\/jats:p>","DOI":"10.1177\/03331024231212895","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T08:19:26Z","timestamp":1702628366000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeting CGRP pathways and aura: A peripheral site with a central effect"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9665","authenticated-orcid":false,"given":"Mohammad Al-Mahdi","family":"Al-Karagholi","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet\u2013 Glostrup, 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