{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:30:20Z","timestamp":1791635420726,"version":"4.3.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Headache is a frequent symptom of infections. We aimed to characterize the clinical phenotype and duration of headache attributed to influenza infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective cohort study done in 53 primary care centers between January and April 2023. Patients were included if they had a confirmed influenza diagnosis, were older than 15 years and had a new-onset headache. Patients\u2019 demographics, prior medical history, headache phenotype and duration, associated symptoms and patients\u2019 outcomes were assessed. The International Classification of Headache Disorders criteria for headache attributed to a systemic viral infection, migraine and tension-type headache were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 478 patients 75 fulfilled eligibility criteria. The mean age was 43, 56% were men, and 27% had a prior headache history. The headache phenotype was a bilateral headache (52%), with frontal topography (48%), pressing quality (61%), moderate intensity, rhinorrhea (79%), nasal congestion (76%), and photophobia (59%). All patients fulfilled headache attributed to acute systemic viral infection criteria, 43% fulfilled migraine criteria and 31% tension-type headache criteria. The median duration of the headache was four (Inter-quartile range: two-six) days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The clinical phenotype of headache attributed to influenza infection was similar to other infections, with more pronounced cranial autonomic symptoms. The headache was an early symptom and was self-limited within a few days.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      The study protocol is registered in ClinicalTrial.gov (NCT05704335)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231212900","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T08:28:32Z","timestamp":1699691312000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["InfluenCEF study: Clinical phenotype and duration of headache attributed to influenza infection"],"prefix":"10.1177","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garc\u00eda-Azor\u00edn","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"},{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Santana-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eugenio","family":"Lozano-Alonso","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General de Salud P\u00fablica e Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n, Gerencia Regional de Salud, Junta de Castilla y Le\u00f3n, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ordax-D\u00edez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n General de Salud P\u00fablica e Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n, Gerencia Regional de Salud, Junta de Castilla y Le\u00f3n, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00e9sica","family":"Gonz\u00e1lez-Osorio","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valladolid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Rojo-Rello","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Eiros","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"},{"name":"National Influenza Centre, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"S\u00e1nchez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"National Influenza Centre, Valladolid, Spain"},{"name":"Fundaci\u00f3n Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n, ICSCYL, Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Recio-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Sierra-Menc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Sanz-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"},{"name":"National Influenza Centre, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-6002","authenticated-orcid":false,"given":"\u00c1ngel Luis","family":"Guerrero-Peral","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"},{"name":"Hospital Cl\u00ednico Universitario de 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