{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:27:40Z","timestamp":1788449260454,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-A49-069-MY3"],"award-info":[{"award-number":["111-2314-B-A49-069-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2314-B-A49-075-MY2"],"award-info":[{"award-number":["111-2314-B-A49-075-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["111-2321-B-A49-011"],"award-info":[{"award-number":["111-2321-B-A49-011"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["112-2321-B-A49-010"],"award-info":[{"award-number":["112-2321-B-A49-010"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The visual cortex is involved in the generation of migraine aura. Voxel-based multivariate analyses applied to this region may provide complementary information about aura mechanisms relative to the commonly used mass-univariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Structural images constrained within the functional resting-state visual networks were obtained in migraine patients with (n\u2009=\u200950) and without (n\u2009=\u200950) visual aura and healthy controls (n\u2009=\u200950). The masked images entered a multivariate analysis in which Gaussian process classification was used to generate pairwise models. Generalizability was assessed by five-fold cross-validation and non-parametric permutation tests were used to estimate significance levels. A univariate voxel-based morphometry analysis was also performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A multivariate pattern of grey matter voxels within the ventral medial visual network contained significant information related to the diagnosis of migraine with visual aura (aura vs. healthy controls: classification accuracy\u2009=\u200978%, p\u2009&lt;\u20090.001; area under the curve\u2009=\u20090.84, p\u2009&lt;\u20090.001; migraine with aura vs. without aura: classification accuracy\u2009=\u200971%, p\u2009&lt;\u20090.001; area under the curve\u2009=\u20090.73, p\u2009&lt;\u20090.003). Furthermore, patients with visual aura exhibited increased grey matter volume in the medial occipital cortex compared to the two other groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Migraine with visual aura is characterized by multivariate and univariate patterns of grey matter changes within the medial occipital cortex that have discriminative power and may reflect pathological mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231222637","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T16:02:23Z","timestamp":1704297743000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Grey matter structure within the visual networks in migraine with aura: multivariate and univariate analyses"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4488-9310","authenticated-orcid":false,"given":"David M.","family":"Niddam","sequence":"first","affiliation":[{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-6555","authenticated-orcid":false,"given":"Kuan-Lin","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Institute of Clinical Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ting","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-3432","authenticated-orcid":false,"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Department of Neurology, The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-5358","authenticated-orcid":false,"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Department of Neurology, The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"bibr1-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1992.1204221.x"},{"key":"bibr2-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00085.x"},{"key":"bibr3-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071582498"},{"key":"bibr4-03331024231222637","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1146302"},{"key":"bibr5-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx382"},{"key":"bibr6-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030402"},{"key":"bibr7-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415583144"},{"key":"bibr8-03331024231222637","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.767"},{"key":"bibr9-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415584360"},{"key":"bibr10-03331024231222637","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1112790"},{"key":"bibr11-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.04.037"},{"key":"bibr12-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1111\/head.14429"},{"key":"bibr13-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr14-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002074"},{"key":"bibr15-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-013-9178-1"},{"key":"bibr16-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.065"},{"key":"bibr17-03331024231222637","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/3206.001.0001"},{"key":"bibr18-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00077"},{"key":"bibr19-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601417103"},{"key":"bibr20-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-019-1008-x"},{"key":"bibr21-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.036"},{"key":"bibr22-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2016.02.007"},{"key":"bibr23-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"bibr24-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0212-7"},{"key":"bibr25-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.044"},{"key":"bibr26-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.1.72"},{"key":"bibr27-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.5.1465"},{"key":"bibr28-03331024231222637","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.1012831"},{"key":"bibr29-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26583"},{"key":"bibr30-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163875"},{"key":"bibr31-03331024231222637","doi-asserted-by":"publisher","DOI":"10.1111\/head.12584"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231222637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024231222637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231222637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:00Z","timestamp":1777387560000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231222637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/03331024231222637"],"URL":"https:\/\/doi.org\/10.1177\/03331024231222637","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"03331024231222637"}}