{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:14:02Z","timestamp":1777490042854,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The present study investigates the wearing-off effect in adults with chronic migraine treated with erenumab or fremanezumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This real-world observational study was based on pre-collected headache diaries from chronic migraine patients in treatment with either monthly injections of 140\u2009mg of erenumab or 225\u2009mg of fremanezumab. Consistent wearing-off was defined as an increase of \u22652 weekly migraine days in the last week compared to the second week over two consecutive 4-week treatment periods. The primary endpoint was wearing-off in the total population. The secondary endpoints were difference in wearing-off in (i) a subgroup of patients treated with erenumab and fremanezumab and (ii) consistent wearing-off in patients with a \u226530% reduction in monthly migraine days, compared to baseline, in the two consecutive treatment months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 100 patients (erenumab: n\u2009=\u200960, fremanezumab: n\u2009=\u200940) were included. Sixty-two out of 100 (62%) patients had consistent \u226530% treatment response on antibody therapy in both months (erenumab: n\u2009=\u200936, fremanezumab: n\u2009=\u200926). There was no consistent wearing-off over the two consecutive months from week 2 to week 4 (3.04%, p\u2009=\u20090.558). There was no wearing-off within the erenumab ( p\u2009=\u20090.194) or the fremanezumab ( p\u2009=\u20090.581) groups. Among the \u226530% treatment responders, there was no consistent wearing-off over the two consecutive months (2.6%, p\u2009=\u20090.573).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no wearing-off in treatment responders, which is in alignment with premarketing data from placebo-controlled phase III studies. These data suggest that patients should be informed upfront that no wearing-off effect is expected because anxiety for attacks at the end of the month per se may generate migraine attacks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231222915","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T14:26:01Z","timestamp":1705069561000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["No wearing-off effect of erenumab or fremanezumab for chronic migraine prevention: a single-center, real-world, observational study"],"prefix":"10.1177","volume":"44","author":[{"given":"Anna Maria","family":"Florescu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e6rke Vig","family":"Lannov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9750-690X","authenticated-orcid":false,"given":"Samaira","family":"Younis","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Kjaer","family":"Cullum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basit Ali","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien Phu","family":"Do","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal Mohammad","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"bibr1-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01232-8"},{"key":"bibr2-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1212"},{"key":"bibr3-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418759786"},{"key":"bibr4-03331024231222915","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101189"},{"key":"bibr5-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"bibr6-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-022-01433-9"},{"key":"bibr7-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-022-00452-3"},{"key":"bibr8-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr9-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01228-4"},{"key":"bibr10-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1111\/head.14403"},{"key":"bibr11-03331024231222915","doi-asserted-by":"publisher","DOI":"10.1111\/head.13994"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231222915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024231222915","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231222915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:00Z","timestamp":1777387560000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231222915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/03331024231222915"],"URL":"https:\/\/doi.org\/10.1177\/03331024231222915","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"03331024231222915"}}