{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:54:08Z","timestamp":1791410048579,"version":"4.3.3"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NIH","award":["R01 DC017261"],"award-info":[{"award-number":["R01 DC017261"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine and vestibular migraine are disorders associated with a heightened motion sensitivity that provoke symptoms of motion-induced nausea and motion sickness. VM affects \u223c3% of adults in the USA and affects three-fold more women than men. Triptans (selective serotonin receptor agonists) relieve migraine pain but lack efficacy for vertigo. Murine models of photophobia and allodynia have used injections of calcitonin gene-related peptide (CGRP) or other migraine triggers, such as sodium nitroprusside (SNP), to induce migraine sensitivities in mice to touch and light. Yet, there is limited research on whether these triggers affect motion-induced nausea in mice, and whether migraine blockers can reduce these migraine symptoms. We hypothesized that systemic delivery of CGRP or SNP will increase motion sickness susceptibility and motion-induced nausea in mouse models, and that migraine blockers can block these changes induced by systemically delivered CGRP or SNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated two measures of motion sickness assessment [motion sickness index (MSI) scoring and motion-induced thermoregulation] after intraperitoneal injections of either CGRP or SNP in C57BL\/6J mice. The drugs olcegepant, sumatriptan and rizatriptan were used to assess the efficacy of migraine blockers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MSI measures were confounded by CGRP\u2019s effect on gastric distress. However, analysis of tail vasodilatations as a surrogate for motion-induced nausea was robust for both migraine triggers. Only olcegepant treatment rescued tail vasodilatations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These preclinical findings support the use of small molecule CGRP receptor antagonists for the treatment of motion-induced nausea of migraine, and show that triptan therapeutics are ineffective against motion-induced nausea of migraine. Trial Registration: Not Applicable<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231223971","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T14:26:35Z","timestamp":1705069595000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Calcitonin gene-related peptide receptor antagonism reduces motion sickness indicators in mouse migraine models"],"prefix":"10.1177","volume":"44","author":[{"given":"Shafaqat M","family":"Rahman","sequence":"first","affiliation":[{"name":"University of Rochester, Department of Biomedical Engineering, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-0278","authenticated-orcid":false,"given":"Anne E","family":"Luebke","sequence":"additional","affiliation":[{"name":"University of Rochester, Department of Biomedical Engineering, Rochester, NY, USA"},{"name":"University of Rochester Medical Center, Department of Neuroscience, Del Monte Institute of Neuroscience, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"bibr1-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10636-0"},{"key":"bibr2-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00345.2016"},{"key":"bibr3-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14889"},{"key":"bibr4-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419869317"},{"key":"bibr5-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2022.02.003"},{"key":"bibr6-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3233\/VES-201644"},{"key":"bibr7-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.812678"},{"key":"bibr8-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/head.13708"},{"key":"bibr9-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-016-0559-7"},{"key":"bibr10-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3233\/VES-200005"},{"key":"bibr11-03331024231223971","doi-asserted-by":"publisher","DOI":"10.4161\/23328940.2014.982047"},{"key":"bibr12-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.03.012"},{"key":"bibr13-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.067"},{"key":"bibr14-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2011.00272.x"},{"key":"bibr15-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra010917"},{"key":"bibr16-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00310.x"},{"key":"bibr17-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.04.012"},{"key":"bibr18-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00363"},{"key":"bibr19-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1177\/03331024231161809"},{"key":"bibr20-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01864.x"},{"key":"bibr21-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010814-124701"},{"key":"bibr22-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1727-09.2009"},{"key":"bibr23-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.861598"},{"key":"bibr24-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0811-5"},{"key":"bibr25-03331024231223971","unstructured":"Lessem SE. QuickStats: percentage of adults who had a severe headache or migraine in the past 3 months, by sex and age group \u2013 National Health Interview Survey, United States, 2018. In:\n                      Statistics NCfH. Morbidity and Mortality Weekly Report\n                      , 27 March. Centers for Disease Control and Prevention or National Center for Health Statistics, 2020."},{"key":"bibr26-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00520"},{"key":"bibr27-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100803"},{"key":"bibr28-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1990.tb00003.x"},{"key":"bibr29-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040414"},{"key":"bibr30-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2305-4"},{"key":"bibr31-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-003-1479-4"},{"key":"bibr32-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00918"},{"key":"bibr33-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21723"},{"key":"bibr34-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419861726"},{"key":"bibr35-03331024231223971","first-page":"264","volume":"1","author":"Russo AF","year":"2009","journal-title":"Mol Cell Pharmacol"},{"key":"bibr36-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1177\/1756285611401647"},{"key":"bibr37-03331024231223971","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.6.212"},{"key":"bibr38-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049476.40047.A3"},{"key":"bibr39-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/head.12110"},{"key":"bibr40-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1177\/1756286420967847"},{"key":"bibr41-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.781"},{"key":"bibr42-03331024231223971","first-page":"163","volume":"50","author":"Berger AA","year":"2020","journal-title":"Psychopharmacol Bull"},{"key":"bibr43-03331024231223971","unstructured":"Baloh RW. Rizatriptan for episodic dizziness in vestibular migraine.\n                      ClinicalTrials.gov identifier: NCT02447991\n                      . 2021. https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT02447991 (accessed 7 January 2022)."},{"key":"bibr44-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/head.13795"},{"key":"bibr45-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/head.13858"},{"key":"bibr46-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1137-21.2022"},{"key":"bibr47-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.11.004"},{"key":"bibr48-03331024231223971","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.820006"},{"key":"bibr49-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1111\/head.14336"},{"key":"bibr50-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04643-8"},{"key":"bibr51-03331024231223971","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_591_19"},{"key":"bibr52-03331024231223971","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynpai.2019.100031"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231223971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024231223971","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024231223971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:01Z","timestamp":1777387561000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/03331024231223971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1177\/03331024231223971"],"URL":"https:\/\/doi.org\/10.1177\/03331024231223971","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.06.03.494762","asserted-by":"object"}]},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"03331024231223971"}}