{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:06:11Z","timestamp":1784084771266,"version":"3.55.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Bio-Medicines, Japan Drug Development & Medical Affairs at Eli Lilly Japan K.K."}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The present study aimed to investigate prescription patterns for patients aged over 17 years with headaches in the REZULT database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional study (Study 1) of the proportion of over-prescription of acute medications (\u226530 tablets\/90 days for triptans, combination non-steroidal anti-inflammatory drugs (NSAIDs) and multiple types; \u226545 tablets\/90 days for single NSAIDs) among patients with headache diagnosed in 2020. We longitudinally studied (Study 2) patients for &gt;2 years from initial headache diagnosis (July 2010 to April 2022). The number of prescribed tablets was counted every 90 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Study 1, headache was diagnosed in 200,055 of 3,638,125 (5.5%) patients: 13,651\/200,055 (6.8%) received acute medication. Single NSAIDs were prescribed to 12,297\/13,651 (90.1%) patients and triptans to 1710\/13,651 (12.5%). Over-prescription was found in 2262\/13,651 (16.6%) patients and 1200\/13,651 (8.8%) patients received prophylactic medication. In Study 2, 408,183\/6,840,618 (6.0%) patients were first diagnosed with headaches, which persisted for \u22652 years. Over time, the proportion of patients over-prescribed acute medications increased. Over 2 years, 37,617\/408,183 (9.2%) patients were over-prescribed acute medications and 29,313\/408,183 (7.2%) patients were prescribed prophylaxis at least once.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>According to real-world data, prophylaxis remains poorly prescribed, and both acute and prophylactic treatment rates for headaches have increased over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024231226177","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T14:57:56Z","timestamp":1704812276000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment patterns and characteristics of headache in patients in Japan: A retrospective cross-sectional and longitudinal analysis of health insurance claims data"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0192-5430","authenticated-orcid":false,"given":"Masahito","family":"Katsuki","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Suwa Red Cross Hospital, Suwa, Nagano, Japan"},{"name":"Headache Outpatient, Suwa Red Cross Hospital, Suwa, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Matsumori","sequence":"additional","affiliation":[{"name":"Sendai Headache and Neurology Clinic, Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Ichihara","sequence":"additional","affiliation":[{"name":"Japan System Techniques Co., Ltd (JAST), Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Japan System Techniques Co., Ltd (JAST), Minato-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Itoigawa General Hospital, Itoigawa, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Itoigawa General Hospital, Itoigawa, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Itoigawa General Hospital, Itoigawa, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suwa Red Cross Hospital, Suwa, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Headache Outpatient, Suwa Red Cross Hospital, Suwa, Nagano, Japan"},{"name":"Department of Neurology, Suwa Red Cross Hospital, Suwa, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomichi","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suwa Red Cross Hospital, Suwa, Nagano, Japan"},{"name":"Headache Outpatient, Suwa Red Cross Hospital, Suwa, Nagano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Itoigawa General Hospital, Itoigawa, Niigata, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"bibr1-03331024231226177","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-021-00305-9"},{"key":"bibr2-03331024231226177","doi-asserted-by":"publisher","DOI":"10.1111\/head.14472"},{"key":"bibr3-03331024231226177","volume-title":"[Clinical Practice Guideline for Headache Disorders 2021] (Japanese)","author":"Headache Clinical Practice Guideline Development Committee C.","year":"2021"},{"key":"bibr4-03331024231226177","first-page":"e25419","volume":"14","author":"Katsuki 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