{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:09:02Z","timestamp":1783584542780,"version":"3.55.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pediatric migraine prophylaxis is indicated when headaches are frequent and\/or disabling. We aimed to conduct a study to compare the efficacy of cinnarizine and amitriptyline in pediatric migraine prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a randomized, double-blind trial, patients aged 4\u201317 years with migraine who were eligible for prophylaxis enrolled. The primary outcome was a reduction response rate of \u226550% with p\u2009&lt;\u20090.005 with respect to headache characteristics. The secondary outcome was migraine disability assessment. We evaluated patients every four weeks for three months: T1: week 4, T2: week 8 and T3: week 12. The safety profile was also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty patients were randomly assigned to each group. However, 43 patients completed the trial. Headache frequency decreased in amitriptyline group more effectively in T1 ( p\u2009=\u20090.004). Amitriptyline was more successful in reducing the headache duration in all three periods ( p\u2009&lt;\u20090.005). There was no significant difference in severity improvement and reducing disability score between the two groups ( p\u2009&gt;\u20090.005). No serious adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both medications are effective in ameliorating migraine headaches and related disabilities. However, amitriptyline appears be a preferable option over cinnarizine, given its faster onset of action, efficacy in reducing headache duration and longer-lasting effects. Trial Registration: The study was registered with the Iranian Registry of Clinical Trials (IRCT) under the code IRCT-20191112045413N1.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241230963","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T04:07:15Z","timestamp":1713586035000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["A comparative study on prophylactic efficacy of cinnarizine and amitriptyline in childhood migraine: a randomized double-blind clinical trial"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-3305","authenticated-orcid":false,"given":"Mehrnaz","family":"Olfat","sequence":"first","affiliation":[{"name":"Division of Pediatric Intensive Care, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh","family":"Hosseinpour","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safdar","family":"Masoumi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Velenjak, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Gogia Rastogi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Vance Hastriter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara Stuart","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Little","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"T Karnik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Hickman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Shervin Badv","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholam Reza","family":"Zamani","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Mohammadpour","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Reza","family":"Ashrafi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Reza","family":"Tavasoli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Neurology, Barrow Neurological Institute at Phoenix Children\u2019s Hospital, Phoenix, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"bibr1-03331024241230963","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11916-020-00892-6","volume":"24","author":"Nieswand V","year":"2020","journal-title":"Curr Pain Headache Rep"},{"key":"bibr2-03331024241230963","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"James SL","year":"2018","journal-title":"The 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