{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:07:00Z","timestamp":1787018820632,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Hypothesis<\/jats:title>\n                    <jats:p>Experimental provocation studies have yielded important insights in migraine pathophysiology. Levcromakalim has been previously shown to induce migraine-like attacks with and without aura. In this study, we aim to further explore the migraine aura-inducing potential of levcromakalim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a double-blind, randomized, placebo-controlled cross-over study, 27 adult participants with migraine with aura received intravenous infusions of levcromakalim and saline. Headache, aura and associated symptoms were evaluated for 24 hours following administration of the study drug. The primary endpoint was occurrence of migraine-like attacks with or without aura in the 24-hour observation period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen participants developed migraine-like attacks on the active day only (P\u2009=\u20090.0098), and four participants developed aura on the active day only (P\u2009=\u20090.68). The median time to onset of migraine-like headache was three hours, and the median time to onset of aura was 27.5 minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\/Interpretation<\/jats:title>\n                    <jats:p>Our findings affirm the potent migraine-inducing effect of levcromakalim. We observed a lower induction-rate of migraine aura than previously reported. Further studies are warranted to identify predictors of migraine aura following levcromakalim.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>ClinicalTrials.gov identifier<\/jats:title>\n                    <jats:p>NCT04905654<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241237247","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T09:07:13Z","timestamp":1710839233000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigations of the migraine-provoking effect of levcromakalim in patients with migraine with aura"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6079-3263","authenticated-orcid":false,"given":"Andreas Vinther","family":"Thomsen","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet \u2013 Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9665","authenticated-orcid":false,"given":"Mohammad Al-Mahdi","family":"Al-Karagholi","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet \u2013 Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0434-7426","authenticated-orcid":false,"given":"Anders","family":"Hougaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Neurology, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5288-3851","authenticated-orcid":false,"given":"Sisse Rye","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Immunology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Birger","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Immunology, Zealand University Hospital, K\u00f8ge, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Folkmann","family":"Hansen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet \u2013 Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Novo Nordisk Foundation Center for Protein Research, Brunak Lab, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet \u2013 Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Knowledge Center on Headache Disorders, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"bibr1-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2014"},{"key":"bibr2-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"bibr3-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01647.x"},{"key":"bibr4-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.137"},{"key":"bibr5-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/119.2.355"},{"key":"bibr6-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415593089"},{"key":"bibr7-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416636097"},{"key":"bibr8-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab136"},{"key":"bibr9-03331024241237247","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz199"},{"key":"bibr10-03331024241237247","first-page":"1","volume-title":"Cephalalgia","volume":"38","author":"Olesen 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