{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T14:29:20Z","timestamp":1778077760034,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Research Foundation for Rigshospitalet and Odense University Hospital","award":["173-A-5083"],"award-info":[{"award-number":["173-A-5083"]}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R 276-2018-403-4"],"award-info":[{"award-number":["R 276-2018-403-4"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Idiopathic intracranial hypertension is a secondary headache disorder potentially causing visual loss. Neurofilament light chain is a candidate, prognostic biomarker, but further studies of neuronal biomarkers are needed. Our objective was to investigate neurofilament light chain in cerebrospinal fluid (cNfL) and plasma (pNfL), amyloid-beta 42 (A\u03b2-42), total-tau and phosphorylated-tau in cerebrospinal fluid in new-onset idiopathic intracranial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case-control study including new-onset idiopathic intracranial hypertension and age, sex and BMI matched controls. Biomarkers were compared between patients and controls and related to papilledema, visual fields and opening pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 37 patients and 35 controls. Patients had higher age-adjusted cNfL (1.4 vs. 0.6\u2009pg\/mL, p-adjusted\u2009&lt;\u20090.001), pNfL (0.5 vs. 0.3\u2009pg\/mL, p-adjusted\u2009&lt;\u20090.001) and total-tau\/A\u03b2-42 (0.12 vs. 0.11, p-adjusted\u2009=\u20090.039). Significant, positive linear correlations were found between cNfL, pNfL, total-tau\/A\u03b2-42 and opening pressure. Patients with severe papilledema had elevated cNfL compared to mild-moderate papilledema (median cNfL: 4.3\u2009pg\/mL (3.7) versus 1.0\u2009pg\/mL (1.4), p-adjusted\u2009=\u20090.009). cNFL was inversely associated with perimetric mean deviation (r\u2009=\u2009\u22120.47, p-adjusted\u2009&lt;\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>cNfL, pNfL and total-tau\/A\u03b2-42 were elevated in new-onset idiopathic intracranial hypertension. cNfL was associated with severity of papilledema and visual field defects at diagnosis. This indicates early axonal damage. Neurofilament light chain is a candidate biomarker for disease severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241248203","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T04:41:02Z","timestamp":1714538462000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Neurofilament light chain is elevated in patients with newly diagnosed idiopathic intracranial hypertension: A prospective study"],"prefix":"10.1177","volume":"44","author":[{"given":"Katrine","family":"Svart","sequence":"first","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5730-0712","authenticated-orcid":false,"given":"Johanne Juhl","family":"Korsb\u00e6k","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Copenhagen, Denmark"},{"name":"University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigmor H\u00f8jland","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Headache Center, Department of Neurology, Rigshospitalet-Glostrup, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Parkner","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, University of Aarhus, \u00c5rhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy S\u00f8nders\u00f8","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, University of Aarhus, \u00c5rhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steen Gregers","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Dementia Research Center, Department of Neurology, Neuroscience Centre, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-8962","authenticated-orcid":false,"given":"Snorre Malm","family":"Hagen","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Ophthalmology, Rigshospitalet-Glostrup, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth Arnberg","family":"Wibroe","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Ophthalmology, Rigshospitalet-Glostrup, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laleh Dehghani","family":"Molander","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-157X","authenticated-orcid":false,"given":"Dagmar","family":"Beier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Odense University Hospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"OPEN, Odense Patient data Explorative Network, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"bibr1-03331024241248203","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/jnnp-2017-317440","volume":"89","author":"Mollan 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