{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:32:47Z","timestamp":1791894767935,"version":"4.3.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Effectiveness of candesartan in migraine prevention is supported by two randomized controlled trials. We aimed to assess the effectiveness, tolerability, and response predictors of candesartan in the preventive treatment of migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Observational, multicenter, prospective cohort study. The 50%, 75% and 30% responder rates, between weeks 8\u201312 and 20\u201324, were compared with the baseline. Treatment emergent adverse effects were systematically evaluated. Response predictors were estimated by multivariate regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eighty-six patients were included, 79.1% females, aged 39.5 (inter-quartile range [IQR] 26.3\u201350.3), with chronic migraine (43.0%), medication overuse headache (55.8%) and a median of two (inter-quartile range: 0.75\u20133) prior preventive treatments. At baseline patients had 14 (10\u201324) headache and 8 (5\u201311) migraine days per month. The 30%, 50% and 75% responder rates were 40%, 34.9% and 15.1% between weeks 8\u201312, and 48.8%, 36%, and 18.6% between weeks 20\u201324. Adverse effects were reported by 30 (34.9%) and 13 (15.1%) patients between weeks 0\u201312 and 12\u201324, leading to discontinuation in 15 (17.4%) patients. Chronic migraine, depression, headache days per month, medication overuse headache, and daily headache at baseline predicted the response between weeks 20\u201324.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Candesartan effectiveness and tolerability in migraine prevention was in line with the clinical trials\u2019 efficacy. Trial registration: The study protocol is registered in ClinicalTrials.gov (NCT04138316).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241248833","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T20:40:20Z","timestamp":1714077620000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["CandeSpartan Study: Candesartan Spanish Response-prediction and Tolerability study in migraine"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garc\u00eda-Azor\u00edn","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"},{"name":"Headache Unit, Department of Neurology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mart\u00ednez-Badillo","sequence":"additional","affiliation":[{"name":"Valladolid East Primary Care, Regional Health Administration, Gerencia Regional de Salud, Junta de Castilla y Leon, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cami\u00f1a Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital Universitari Son Espases, Palma de Mallorca, Spain"},{"name":"Department of Neurology, Clinica Rotger Quironsalud, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz","family":"Gago-Veiga","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Instituto de Investigaci\u00f3n Sanitaria, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-4210","authenticated-orcid":false,"given":"Noemi","family":"Moroll\u00f3n S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Headache and Neuralgia Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Gonz\u00e1lez-Quintanilla","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital Universitario Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7034-682X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Porta-Etessam","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Sierra-Menc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital Cl\u00ednico San Carlos, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00e9sica","family":"Gonz\u00e1lez-Osorio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8609-7385","authenticated-orcid":false,"given":"Marcos","family":"Polanco-Fernandez","sequence":"additional","affiliation":[{"name":"Headache Unit, Department of Neurology, Hospital Universitario Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Recio-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Belvis Nieto","sequence":"additional","affiliation":[{"name":"Headache and Neuralgia Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-6002","authenticated-orcid":false,"given":"Angel Luis","family":"Guerrero-Peral","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Universidad de Valladolid, Valladolid, Spain"},{"name":"Headache Unit, Department of Neurology, Hospital Cl\u00ednico Universitario de Valladolid, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"bibr1-03331024241248833","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1527-3466.2004.tb00146.x","volume":"22","author":"Gleiter CH","year":"2004","journal-title":"Cardiovasc Drug Rev"},{"key":"bibr2-03331024241248833","first-page":"PL183","volume":"51","author":"Mizuno K","year":"1992","journal-title":"Life Sci"},{"key":"bibr3-03331024241248833","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(93)90153-9","volume":"235","author":"Kinugawa K","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"bibr4-03331024241248833","unstructured":"European Medicines Agency. 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Manual de pr\u00e1ctica cl\u00ednica en cefaleas. Recomendaciones diagn\u00f3stico-terap\u00e9uticas de la Sociedad Espa\u00f1ola de Neurolog\u00eda 2020. Ed. Luzan 5, https:\/\/www.sen.es\/profesionales\/guias-y-protocolos (Accessed on 14 October 2023)."},{"key":"bibr15-03331024241248833","unstructured":"Good clinical practice: consolidate guideline. In: Proceedings of the International Conference on Harmonisation of Technical Requirements for Registrations of Pharmaceuticals for Human Use. 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