{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:30:39Z","timestamp":1783384239382,"version":"3.54.6"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["Vici grant 09150181910040"],"award-info":[{"award-number":["Vici grant 09150181910040"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups &lt;50 years and \u226550 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females &lt;50 compared with males &lt;50 years of age. No differences were observed between the older age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241254088","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T19:10:46Z","timestamp":1721761846000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries: implications for migraine"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5078-6764","authenticated-orcid":false,"given":"Tessa","family":"de Vries","sequence":"first","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre M.","family":"Boucherie","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayi Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00edsa","family":"Rubio-Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Labastida-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sieneke","family":"Labruijere","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoon","family":"van den Bogaerdt","sequence":"additional","affiliation":[{"name":"Heart Valve Department, ETB-BISLIFE, Beverwijk, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Dammers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H. Jan","family":"Danser","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"MaassenVanDenBrink","sequence":"additional","affiliation":[{"name":"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"bibr1-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30293-9"},{"key":"bibr2-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1111\/head.14488"},{"key":"bibr3-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000133134.68143.2E"},{"key":"bibr4-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2003.00480.x"},{"key":"bibr5-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-009-0065-2"},{"key":"bibr6-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-2906-9"},{"key":"bibr7-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130338.62037.CC"},{"key":"bibr8-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005855"},{"key":"bibr9-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107528"},{"key":"bibr10-03331024241254088","doi-asserted-by":"publisher","DOI":"10.3109\/00365519009091595"},{"key":"bibr11-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207114"},{"key":"bibr12-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417739584"},{"key":"bibr13-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2007.00714.x"},{"key":"bibr14-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00526.x"},{"key":"bibr15-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2006.00596.x"},{"key":"bibr16-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419884943"},{"key":"bibr17-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.1.19"},{"key":"bibr18-03331024241254088","first-page":"5","volume":"3","author":"Blom J","year":"2022","journal-title":"Nederlands Huisartsen Genootschap"},{"key":"bibr19-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011216"},{"key":"bibr20-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51640"},{"key":"bibr21-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.01.024"},{"key":"bibr22-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(98)00066-7"},{"key":"bibr23-03331024241254088","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111768"},{"key":"bibr24-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14075"},{"key":"bibr25-03331024241254088","volume-title":"17th European Headache Congress","author":"de Vries T","year":"2023"},{"key":"bibr26-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(03)00032-6"},{"key":"bibr27-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.03.006"},{"key":"bibr28-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.015628"},{"key":"bibr29-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag058"},{"key":"bibr30-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416668659"},{"key":"bibr31-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01334-3"},{"key":"bibr32-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1080\/cmt.5.1.15.25"},{"key":"bibr33-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2012.01.006"},{"key":"bibr34-03331024241254088","unstructured":"Leung G. Age and testosterone-dependent change in the expression of calcitonin-gene related peptide receptors in rat basilar arteries. In:\n                      BPS Focused Meeting on Neuropeptides\n                      King's College London, UK, 7-9 June 2012, Vol 10 Issue 2, 042P. pA2 online: British Pharmacological Society."},{"key":"bibr35-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1080\/tam.5.2.98.102"},{"key":"bibr36-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241238153"},{"key":"bibr37-03331024241254088","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16322"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241254088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024241254088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241254088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:24Z","timestamp":1777387584000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024241254088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/03331024241254088"],"URL":"https:\/\/doi.org\/10.1177\/03331024241254088","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"article-number":"03331024241254088"}}