{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:38:47Z","timestamp":1793407127037,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on drug-induced reversible cerebral vasoconstriction syndrome (RCVS) are scarce. We aimed to describe RCVS characteristics with drugs previously identified as associated with RCVS and investigate potential signals related to other drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      VigiBase\n                      <jats:sup>\u00ae<\/jats:sup>\n                      was queried for all reports of RCVS until 31 May 2023. A descriptive study was performed on reports concerning drug classes known to precipitate RCVS. To identify new drugs, a disproportionality analysis was conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 560 reports were included. RCVS occurred in patients aged between 45\u201364 years (40%) and 18\u201344 years (35%), mainly in females (72.5%). Drugs were antidepressants (38.4%), triptans (6.4%), nasal decongestants (3.7%) and immunosupressants (8.7%). In 50 cases, antidepressants were in association with drugs known to precipitate RCVS. The median time to onset was 195 days for antidepressants and much shorter (1\u201310 days) for triptans, nasal decongestants and immunosuppressants. The outcome was favorable in 87% of cases, and fatal in 4.4%. We found a disproportionality signal with 14 drugs: glucocorticoids, bupropion, varenicline, mycophenolic acid, aripiprazole, trazodone, monoclonal antibodies (erenumab, ustekinumab and tocilizumab), leuprorelin and anastrozole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study confirms the role of vasoconstrictors in the onset of RCVS, particularly when used in combination and found potential signals, which may help clinicians envisage an iatrogenic etiology of RCVS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241267316","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T19:40:26Z","timestamp":1723318826000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Drugs associated with reversible cerebral vasoconstriction syndrome: A pharmacovigilance study in vigiBase\n                    <sup>\u00ae<\/sup>"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6499-1525","authenticated-orcid":false,"given":"Sylvie","family":"Favreli\u00e8re","sequence":"first","affiliation":[{"name":"Service de Pharmacologie Clinique \u2013 Centre R\u00e9gional de Pharmacovigilance de Poitiers, CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mah\u00e9","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance de Nantes, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenaelle","family":"Veyrac","sequence":"additional","affiliation":[{"name":"Centre R\u00e9gional de Pharmacovigilance de Nantes, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Philippe","family":"Neau","sequence":"additional","affiliation":[{"name":"Service de Neurologie CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lafay-Chebassier","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique \u2013 Centre R\u00e9gional de Pharmacovigilance de Poitiers, CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christine","family":"P\u00e9rault-Pochat","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie Clinique \u2013 Centre R\u00e9gional de Pharmacovigilance de Poitiers, CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,10]]},"reference":[{"key":"bibr1-03331024241267316","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.9.1159"},{"key":"bibr2-03331024241267316","first-page":"2046","volume":"20","author":"Calabrese LH","year":"1993","journal-title":"J 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