{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:07:01Z","timestamp":1787018821976,"version":"build-2736575974"},"reference-count":25,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine presents significant health and economic challenges. Despite the widespread use of triptans, some patients discontinue them because of insufficient relief or adverse effects. Using national registers, the present study investigates the excess costs and labour market disaffiliation of Danish patients discontinuing triptan treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included all individuals \u226518 years (\u201cpatients\u201d) who discontinued redemption of triptan prescriptions between 1998 and 2019. They were categorized by number of distinct triptans redeemed before discontinuation: one, two or three or more. A control group was established from the general population without triptan redemptions, three per patient, matched by year of birth, sex and region of residence. We estimated excess direct and indirect costs from 5 years prior (\u201cyear \u22125\u201d) to 10 years post (\u201cyear 10\u201d) the first triptan redemption.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 211,026 patients who discontinued triptan redemption, 82% after one, 14% after two and 4% after three or more distinct triptans. Over the period from year \u22125 to year 10, average excess healthcare costs per patient in these cohorts were EUR 9,554, EUR 10,942 and EUR 12,812 respectively. Over the same period, these patients earned EUR 27,964, EUR 35,920 and EUR 50,076 less than their respective controls, and received higher public transfer payments of EUR 20,181, EUR 23,264 and EUR 26,459.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Triptan discontinuers, who appear to have exhausted all current treatment avenues, face high direct and very high indirect excess costs attributable to migraine, and experience substantial increased labour market disaffiliation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241269758","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T04:52:15Z","timestamp":1727326335000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cost of illness and labour market disaffiliation among patients with migraine discontinuing triptan treatment: A Danish nationwide register study from  1995 to 2021"],"prefix":"10.1177","volume":"44","author":[{"given":"Messoud","family":"Ashina","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"},{"name":"Danish Knowledge Center on Headache Disorders, Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark"},{"name":"Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Division of Brain Sciences, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob M\u00f8ller","family":"Hansen","sequence":"additional","affiliation":[{"name":"Private Neurology Practice, Slagelse, Region Zealand, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Sloth","family":"Hauberg","sequence":"additional","affiliation":[{"name":"Pfizer Denmark; Ballerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla Sofie","family":"L\u00f8nberg","sequence":"additional","affiliation":[{"name":"Pfizer Denmark; Ballerup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Spanggaard","sequence":"additional","affiliation":[{"name":"EY, Copenhagen, Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-1736","authenticated-orcid":false,"given":"Jens","family":"Olsen","sequence":"additional","affiliation":[{"name":"EY, Copenhagen, Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Elkj\u00e6r","family":"Stallknecht","sequence":"additional","affiliation":[{"name":"EY, Copenhagen, Frederiksberg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6703-7762","authenticated-orcid":false,"given":"Thomas Folkmann","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital - Rigshospitalet, Glostrup, Denmark"},{"name":"Translational Research Centre, Neurogenomic group, Copenhagen University Hospital \u2013 Rigshospitalet Glostrup, Glostrup, \rDenmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"bibr1-03331024241269758","unstructured":"Institute for Health Metrics and Evaluation. GBD 2019 cause and risk summaries. Migraine \u2013 Level 4 Cause, https:\/\/www.healthdata.org\/results\/gbd_summaries\/2019\/migraine-level-4-cause (2019, accessed 3 March 2022)."},{"key":"bibr2-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1111\/head.14247"},{"key":"bibr3-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1080\/08039480801979792"},{"key":"bibr4-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-005-3778-5"},{"key":"bibr5-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2021.75"},{"key":"bibr6-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1111\/head.14289"},{"key":"bibr7-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03612.x"},{"key":"bibr8-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32160-7"},{"key":"bibr9-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01228-4"},{"key":"bibr10-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-007-0428-1"},{"key":"bibr11-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-021-00509-5"},{"key":"bibr12-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1177\/0333102421991809"},{"key":"bibr13-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15657"},{"key":"bibr14-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"bibr15-03331024241269758","unstructured":"Danish Health Data Authority. Danish National Patient Register. https:\/\/sundhedsdatastyrelsen.dk\/da\/english\/health_data_and_registers"},{"key":"bibr16-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394718"},{"key":"bibr17-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810394717"},{"key":"bibr18-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1177\/1403494811405098"},{"key":"bibr19-03331024241269758","unstructured":"Danske Regioner. Pris- og l\u00f8nudviklingen 1988\n                      \u2013\n                      2020, https:\/\/www.regioner.dk\/aftaler-og-oekonomi\/oekonomisk-vejledning\/oekonomisk-vejledning-2020 (2020, accessed 14 January 2021)."},{"key":"bibr20-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-020-00196-2"},{"key":"bibr21-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1007\/s40122-019-0133-1"},{"key":"bibr22-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1177\/0333102410381145"},{"key":"bibr23-03331024241269758","doi-asserted-by":"publisher","DOI":"10.1111\/head.13421"},{"key":"bibr24-03331024241269758","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S91125"},{"key":"bibr25-03331024241269758","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S341480"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241269758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024241269758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241269758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:29Z","timestamp":1777387589000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024241269758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/03331024241269758"],"URL":"https:\/\/doi.org\/10.1177\/03331024241269758","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"article-number":"03331024241269758"}}