{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:21:29Z","timestamp":1790713289887,"version":"4.1.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Monoclonal antibodies targeting calcitonin gene-related peptide (CGRP-mAbs) are approved for adult migraine prevention but pose safety concerns in pregnancy. We assess the safety of CGRP-mAbs in the periconceptional period through a case series and literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Six migraine-diagnosed women received CGRP-mAbs; treatment ceased upon pregnancy. We collected data and conducted safety assessments. To provide a comprehensive context, we performed a literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The series includes three erenumab, two fremanezumab and one galcanezumab case. A fremanezumab recipient experienced miscarriage; severe perinatal asphyxia linked to dystocia occurred with erenumab (140\u2005mg). Database reviews revealed 63 spontaneous abortions, eight premature births, and seven birth defects among 286 World Health Organization and 65 European Medicines Agency cases. These rates align with untreated population rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CGRP-mAbs use in the periconceptional period does not lead to clinically significant increase in pregnancy-related pathology or adverse effects on newborns within our case series and the literature reviewed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241273966","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T11:12:09Z","timestamp":1727176329000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Case series on monoclonal antibodies targeting calcitonin gene-related peptide in migraine patients during pregnancy: Enhancing safety data"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1730-2448","authenticated-orcid":false,"given":"Iker","family":"Elosua-Bayes","sequence":"first","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-9401","authenticated-orcid":false,"given":"Alicia","family":"Alpuente","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Headache and Craniofacial pain Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Melgarejo","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-0267","authenticated-orcid":false,"given":"Edoardo","family":"Caronna","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Headache and Craniofacial pain Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4134","authenticated-orcid":false,"given":"Marta","family":"Torres-Ferr\u00fas","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Headache and Craniofacial pain Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-4702","authenticated-orcid":false,"given":"Patricia","family":"Pozo-Rosich","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"},{"name":"Headache and Craniofacial pain Unit, Neurology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"bibr1-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30435-0"},{"key":"bibr2-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00409-9"},{"key":"bibr3-03331024241273966","first-page":"2145","volume":"42","author":"Fofi L","year":"2021","journal-title":"Neurol Sci Off J Ital Neurol Soc Ital Soc Clin Neurophysiol"},{"key":"bibr4-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1111\/head.14305"},{"key":"bibr5-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1111\/head.14393"},{"key":"bibr6-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1177\/03331024231158083"},{"key":"bibr7-03331024241273966","unstructured":"European Medicines Agency: EMA\/708631\/2018 \u2013 Assessment report: Emgality."},{"key":"bibr8-03331024241273966","unstructured":"European Medicines Agency: EMA\/118499\/2019 \u2013 Assessment report: Ajovy."},{"key":"bibr9-03331024241273966","unstructured":"European Medicines Agency: EMA\/CHMP\/413393\/2018 \u2013 Assessment report: Aimovig."},{"key":"bibr10-03331024241273966","volume":"380","author":"Crump C","year":"2023","journal-title":"BMJ"},{"key":"bibr11-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.05.013"},{"key":"bibr12-03331024241273966","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260718"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241273966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024241273966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241273966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:29Z","timestamp":1777387589000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024241273966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/03331024241273966"],"URL":"https:\/\/doi.org\/10.1177\/03331024241273966","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"article-number":"03331024241273966"}}