{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:16:48Z","timestamp":1793305008081,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It is still debatable whether the mechanisms underlying photophobia are related to altered visual cortex excitability or specific abnormalities of colour-related focal macular retino-thalamic information processing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study examined Ganzfeld blue-red (B-R) and blue-yellow (B-Y) focal macular cone flash ERG (ffERG) and focal-flash visual evoked potentials (ffVEPs) simultaneously in a group of migraine patients with (n\u2009=\u200918) and without (n\u2009=\u200919) aura during the interictal phase, in comparison to a group of healthy volunteers (HVs) (n\u2009=\u200920). We correlate the resulting retinal and cortical electrophysiological responses with subjective discomfort from exposure to bright light verified on a numerical scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to HVs, the amplitude and phase of the first and second harmonic of ffERG and ffVEPs were non-significantly different in migraine patients without aura and migraine patients with aura for both the B-R and the B-Y focal stimuli. Pearson's correlation test did not disclose correlations between clinical variables, including the photophobia scale and electrophysiological variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results do not favour interictal functional abnormalities in L-M- and S-cone opponent visual pathways in patients with migraine. They also suggest that the discomfort resulting from exposure to bright light is not related to focal macular retinal-to-visual cortex pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024241276501","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:47:55Z","timestamp":1726454875000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Lack of a direct link between macular cones function and photophobia in interictal migraine"],"prefix":"10.1177","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-950X","authenticated-orcid":false,"given":"Francesco","family":"Casillo","sequence":"first","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Renzo","sequence":"additional","affiliation":[{"name":"IRCCS \u2013 Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4231-4417","authenticated-orcid":false,"given":"Gabriele","family":"Sebastianelli","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Abagnale","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Endocrine-Metabolic Diseases, and Ageing, National Institute of Health, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherubino","family":"Di Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Serrao","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetto","family":"Falsini","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy"},{"name":"Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Parisi","sequence":"additional","affiliation":[{"name":"IRCCS \u2013 Fondazione Bietti, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-6925","authenticated-orcid":false,"given":"Gianluca","family":"Coppola","sequence":"additional","affiliation":[{"name":"Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,9,15]]},"reference":[{"key":"bibr1-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0b013e3182474548"},{"key":"bibr2-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr3-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1997.3708492.x"},{"key":"bibr4-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1177\/0333102414547782"},{"key":"bibr5-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415606080"},{"key":"bibr6-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.190223"},{"key":"bibr7-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2967-16.2016"},{"key":"bibr8-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2475"},{"key":"bibr9-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.02.004"},{"key":"bibr10-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00831.x"},{"key":"bibr11-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2000.00028.x"},{"key":"bibr12-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww119"},{"key":"bibr13-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-1313.2010.00758.x"},{"key":"bibr14-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-017-9619-5"},{"key":"bibr15-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1167\/8.15.11"},{"key":"bibr16-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1080\/713826267"},{"key":"bibr17-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(00)00021-3"},{"key":"bibr18-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(91)90099-P"},{"key":"bibr19-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020505104334"},{"key":"bibr20-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(99)00027-9"},{"key":"bibr21-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(03)00049-1"},{"key":"bibr22-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-022-09872-0"},{"key":"bibr23-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001434"},{"key":"bibr24-03331024241276501","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7604"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241276501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024241276501","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024241276501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:29Z","timestamp":1777387589000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024241276501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/03331024241276501"],"URL":"https:\/\/doi.org\/10.1177\/03331024241276501","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9]]},"article-number":"03331024241276501"}}