{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:22:55Z","timestamp":1783642975502,"version":"3.55.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>New daily persistent headache (NDPH) is an often treatment-refractory primary headache disorder with a lack of evidence base for treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed an observational study using prospectively collected data in consecutive patients with NDPH, chronic migraine with daily headache (daily-CM) and without daily headache (non-daily-CM). Patients were treated with two cycles of OnabotulinumtoxinA. Propensity score matching was used to control for imbalances between the groups. The primary outcome measure was the proportion who experienced a\u2009\u2265\u200930% improvement in monthly moderate-to-severe headache days at 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 58 patients with NDPH, 148 with daily-CM, and 84 with non-daily-CM. In NDPH, 34.5% of patients experienced a\u2009\u2265\u200930% improvement in monthly moderate-to-severe headache days, compared to 43.2% in daily-CM and 51.2% in non-daily CM. In NDPH, 6.9% experienced an improvement in monthly headache days, 27.6% an improvement in headache severity, 25.9% a\u2009\u2265\u20096 point improvement in HIT-6 score, and 59% a patient reported improvement. There was no significant difference in response rates between the three groups. Adverse event rates were similar in all groups and there were no serious adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OnabotulinumtoxinA is effective in approximately 1\/3 patients with NDPH and has a favourable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251317448","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T01:36:21Z","timestamp":1739151381000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["OnabotulinumtoxinA for primary  new daily persistent headache and comparison to chronic migraine"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-6549","authenticated-orcid":false,"given":"Sanjay","family":"Cheema","sequence":"first","affiliation":[{"name":"Headache and Facial Pain Group, University College London Queen Square Institute of Neurology, London, UK"},{"name":"Headache and Facial Pain Group, The National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie","family":"Lagrata","sequence":"additional","affiliation":[{"name":"Headache and Facial Pain Group, The National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija Rerhou","family":"Rantell","sequence":"additional","affiliation":[{"name":"Biostatistics, Education Unit, University College London Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Headache and Facial Pain Group, The National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salwa","family":"Kamourieh","sequence":"additional","affiliation":[{"name":"Headache and Facial Pain Group, University College London Queen Square Institute of Neurology, London, UK"},{"name":"Headache and Facial Pain Group, The National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4960-2294","authenticated-orcid":false,"given":"Manjit Singh","family":"Matharu","sequence":"additional","affiliation":[{"name":"Headache and Facial Pain Group, University College London Queen Square Institute of Neurology, London, UK"},{"name":"Headache and Facial Pain Group, The National Hospital for Neurology and Neurosurgery, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"key":"bibr1-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr2-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1177\/03331024231168089"},{"key":"bibr3-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00326.x"},{"key":"bibr4-03331024251317448","doi-asserted-by":"crossref","DOI":"10.1136\/jnnp.72.3.297","volume":"72","author":"Goadsby PJ","year":"2002","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"bibr5-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2001.01152.x"},{"key":"bibr6-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01678.x"},{"key":"bibr7-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-008-0078-y"},{"key":"bibr8-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-16-S1-A119"},{"key":"bibr9-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000313"},{"key":"bibr10-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2009.01842.x"},{"key":"bibr11-03331024251317448","unstructured":"ClinicalTrials.gov. OnabotulinumtoxinA for the Treatment of New Daily Persistent Headache: an Open Label Study, https:\/\/clinicaltrials.gov\/ct2\/show\/NCT01920945 (2016, accessed 18 April 2022)."},{"key":"bibr12-03331024251317448","unstructured":"National Institute for Health and Care Excellence. Botulinum toxin type A for the prevention of headaches in adults with chronic migraine. Technology appraisal guidance [TA260], https:\/\/www.nice.org.uk\/guidance\/ta260 (2012, accessed 21 April 2023)."},{"key":"bibr13-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01766.x"},{"key":"bibr14-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026119331193"},{"key":"bibr15-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"bibr16-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1111\/head.13946"},{"key":"bibr17-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B"},{"key":"bibr18-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3181c1328f"},{"key":"bibr19-03331024251317448","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.9.4.403"},{"key":"bibr20-03331024251317448","unstructured":"Ridgeway G, McCaffrey D, Morral A, et al. 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