{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:16:26Z","timestamp":1793740586725,"version":"4.6.1"},"reference-count":57,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V108C-092, V109C-096, V110C-111, V111C-161, V112C-"],"award-info":[{"award-number":["V108C-092, V109C-096, V110C-111, V111C-161, V112C-"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013227","name":"Health Promotion Administration, Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW112-TDU-B-211-144001"],"award-info":[{"award-number":["MOHW112-TDU-B-211-144001"]}],"id":[{"id":"10.13039\/100013227","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taiwan National Science and Technology Council","award":["110-2321-B-010-005, 111-2321-B-A49-004, 111-2314-B"],"award-info":[{"award-number":["110-2321-B-010-005, 111-2321-B-A49-004, 111-2314-B"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The present study aimed to evaluate the risk and impact of fibromyalgia in relation to headache frequency in migraine patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study involved migraine patients from a regional hospital and a tertiary medical center. Diagnoses of migraine and fibromyalgia were made according to the International Classification of Headache Disorders, 3rd edition, and the modified 2016 American College of Rheumatology diagnostic criteria, respectively. Clinical data, including Fibromyalgia Symptoms (FS) scale and revised Fibromyalgia Impact Questionnaire (FIQR), were collected systematically by questionnaires-based interviews. Patients were categorized based on monthly headache day (MHD) cut-offs derived from decision tree analysis based on the chi-squared automatic interaction detection algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study involved 2082 migraine patients (1619 female\/463 male, mean\u2009\u00b1\u2009SD age 39.3\u2009\u00b1\u200912.0\u00a0years), including 132 with fibromyalgia (118 female\/14 male, mean\u2009\u00b1\u2009SD age 44.1\u2009\u00b1\u200912.7\u00a0years) (6.3%). Patients were divided into three groups: \u22649 MHDs (n\u2009=\u2009924), 10\u201320 MHDs (n\u2009=\u2009745) and \u226521 MHDs (n\u2009=\u2009413). The percentage of fibromyalgia increased with headache frequency ( p\u2009&lt;\u20090.001). When compared with patients with \u22649 MHDs (2.8%), those with 10\u201320 MHDs (6.2%) (odds ratio (OR) =\u20091.90, 95% confidence interval (CI)\u2009=\u20091.11\u20133.23, p\u2009=\u20090.019) and \u226521 MHDs (14.5%) (OR =\u20093.68, 95% CI =\u20092.08\u20136.49, p\u2009&lt;\u20090.001) were more likely to have fibromyalgia. Patients with more frequent headaches had higher FS and FIQR scores (all p\u2009&lt;\u20090.001 between MHD categories).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was an independent dose\u2013response association between headache frequency and odds, severity, and impact of fibromyalgia in migraine patients. For migraine patients with a higher headache frequency, the potential risk of comorbid fibromyalgia should not be overlooked given its association with more severe clinical manifestations and greater disability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251317486","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T01:51:10Z","timestamp":1740361870000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between headache frequency and risk for fibromyalgia in patients with migraine"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0498-4695","authenticated-orcid":false,"given":"Yen-Hui","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan"},{"name":"Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Neurology, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Shiang","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3492-9902","authenticated-orcid":false,"given":"Shih-Pin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Division of Translational Research, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2360-0693","authenticated-orcid":false,"given":"Yu-Hsiang","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ta","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keelung Hospital, Ministry of Health and Welfare, Keelung, Taiwan"},{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-5358","authenticated-orcid":false,"given":"Shuu-Jiun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-3432","authenticated-orcid":false,"given":"Yen-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan"},{"name":"Brain Research Center, National Yang Ming Chiao Tung University, Taipei, 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