{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:44:02Z","timestamp":1793169842804,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A2B5B01001933"],"award-info":[{"award-number":["2022R1A2B5B01001933"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Few studies have examined plasma calcitonin gene-related peptide (CGRP) levels in individuals with vestibular migraine (VM), with inconsistent findings. Additionally, salivary CGRP levels in VM have not been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Interictal plasma and salivary CGRP levels were measured using an enzyme-linked immunosorbent assay in participants with VM corresponding to episodic migraine (VM, n\u2009=\u200981), chronic migraine without vestibular symptoms (CM, n\u2009=\u200973) and healthy controls (HC, n\u2009=\u200959).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma CGRP levels in VM with episodic migraine participants were significantly lower than those in participants with CM (median\u2009=\u200937.1 pg\/mL, interquartile range (IQR)\u2009=\u200922.4\u201360.4 pg\/mL vs. median\u2009=\u200974.6 pg\/mL, IQR \u2009=\u200949.6\u2013101.6 pg\/mL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but did not significantly differ from levels in HC. Similarly, salivary CGRP levels were also significantly lower in VM compared to CM (median\u2009=\u200954.5 pg\/mL, IQR =\u200937.0\u201383.4 pg\/mL vs. median\u2009=\u200972.0 pg\/mL, IQR \u2009=\u200956.5\u201396.2 pg\/mL;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.036), with no significant difference observed between VM and HC. Receiver operating characteristic analysis showed that plasma CGRP levels effectively differentiated CM from VM corresponding to episodic migraine, achieving an area under the curve of 0.88. No significant correlations were found between plasma or salivary CGRP levels and clinical features of CM and VM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Interictal plasma and salivary CGRP levels are unlikely to serve a biomarkers for VM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251322418","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T11:29:36Z","timestamp":1742210976000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["No change in interictal plasma and salivary CGRP levels in individuals with vestibular migraine corresponding to episodic migraine"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3288-845X","authenticated-orcid":false,"given":"Yutong","family":"Bai","sequence":"first","affiliation":[{"name":"Jeonbuk National University School of Medicine"},{"name":"Jeonbuk National University Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6221-1346","authenticated-orcid":false,"given":"Min Kyung","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5629-6136","authenticated-orcid":false,"given":"Jin-Ju","family":"Kang","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhee","family":"Chae","sequence":"additional","affiliation":[{"name":"Jeonbuk National University Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Dieterich","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians-University, Munich"},{"name":"Ludwig-Maximilians-University, Munich"},{"name":"Munich Cluster for Systems Neurology (SyNergy), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1680","authenticated-orcid":false,"given":"Sun-Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Jeonbuk National University School of Medicine"},{"name":"Jeonbuk National University Hospital"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416646755"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050478"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.436"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/VES-2012-0453"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.14309"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.812678"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230214"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2002.00310.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-024-01769-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.00836.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6cb72"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01154-x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-024-00792-9"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90981-X"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)91593-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3336-13.2014"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.799002"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1681994"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2478\/fzm-2021-0014"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-21131-4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12250"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000002438"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-075141"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0285435"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024211024161"},{"key":"e_1_3_3_28_2","volume-title":"Procedures for the handling and processing of blood specimens for common laboratory tests","author":"Institute CLS","year":"2010","unstructured":"Institute CLS. Procedures for the handling and processing of blood specimens for common laboratory tests. Wayne, PA: Clinical Laboratory Standards Institute, 2010."},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419869317"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01145-y"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01182-7"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.930383"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy355"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26658"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26472"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2022.100453"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2018.31"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1993.hed33040210.x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409351807"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024211040467"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024251322418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024251322418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024251322418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:46:47Z","timestamp":1777387607000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024251322418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/03331024251322418"],"URL":"https:\/\/doi.org\/10.1177\/03331024251322418","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"article-number":"03331024251322418"}}