{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:35:04Z","timestamp":1780490104351,"version":"3.54.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diffusion tensor imaging (DTI) may demonstrate microstructural changes in diseased trigeminal nerves. Few prognostic indicators for long-term pain freedom after microvascular decompression (MVD) of the trigeminal nerve have been identified. The present study aimed to determine whether microstructural changes from DTI are present in the trigeminal nerve of patients with classical trigeminal neuralgia (cTN) due to arterial compression or deformation and whether they may be used to predict surgical success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with a diagnosis of cTN due to arterial compression or deformation that underwent MVD from October 2013 until December 2020, with high resolution 3T magnetic resonance imaging DTI, and over two years of post-surgical follow-up were included in this study. The microstructural metrics of the symptomatic and asymptomatic trigeminal nerve were compared using a paired, two-sided Student\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test. Differences between the microstructural metrics of the symptomatic nerve between treatment responders and treatment non-responders were assessed using Welch's\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test due to unequal variances and\/or unequal sample sizes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-eight patients met inclusion criteria and were analyzed. There was no significant difference in fractional anisotropy (FA) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.3658), mean diffusivity (MD) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.1734) and radial diffusivity (RD) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.6586) between the symptomatic and asymptomatic nerve. There was a significant difference in AD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0186). However, after the sequential modified Bonferroni correction, the difference in AD no longer reached significance. There was no significant difference in FA (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.7556), MD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.8915), RD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.4324) and AD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.9918) in the symptomatic nerve between the treatment responders and non-responders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DTI may not reliably predict outcomes of microvascular decompression in patients with cTN due to arterial compression or deformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251322505","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T07:01:22Z","timestamp":1753945282000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["An analysis of diffusion tensor imaging in classical trigeminal neuralgia"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8107-5538","authenticated-orcid":false,"given":"Margaret","family":"Tugend","sequence":"first","affiliation":[{"name":"Columbia University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby T.","family":"Joncas","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Traylor","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0380-6301","authenticated-orcid":false,"given":"Raymond F.","family":"Sekula","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"International Headache Society. International classification of headache disorders\u20133. https:\/\/ichd-3.org\/13-painful-cranial-neuropathies-and-other-facial-pains\/13-1-trigeminal-neuralgia\/13-1-1-classical-trigeminal-neuralgia (2021 March 1 2025)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604253341701"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2012.01.040"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.9.JNS181208"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz376"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.3.0527"},{"key":"e_1_3_2_8_2","first-page":"671730","article-title":"DTI Measurements in multiple sclerosis: evaluation of brain damage and clinical implications","volume":"2013","author":"Sbardella E","year":"2013","unstructured":"Sbardella E, Tona F, Petsas N, et al. DTI Measurements in multiple sclerosis: evaluation of brain damage and clinical implications. 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