{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:18:11Z","timestamp":1790713091396,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on the effectiveness of preventive treatments on menstrually-related migraine (MRM) is scarce. Our objective was to analyze the efficacy of anti-calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) and onabotulinumtoxinA (BTX-A) in the reduction of perimenstrual headache days (PHD) and perimenstrual migraine days (PMD) compared to non-perimenstrual headache days (non-PHD) and non-perimenstrual migraine days (non-PMD) per month in women with MRM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted including females with menstruation and headache records, treated with either anti-CGRP mAbs or BTX-A. Patients completed e-Diary one month before and three months after preventive treatment. We collected clinical data and analyzed PHD\/PMD and non-PHD\/non-PMD before and after treatment. Additional analyses included PHD\/PMD and non-PHD\/non-PMD comparisons grouped by aura, episodic\/chronic migraine, treatment and contraceptive intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We analyzed data from 113 females with a median (range) age of 39.0 (33.0\u201345.0) years. When combining patients treated with anti-CGRP mAbs or BTX-A, a median (range) of 2.0 (2.0\u20133.0) PHD\/month (corresponding to 13.6% baseline monthly headache days (MHD)) and 13.0 (9.0\u201317.0) non-PHD\/month pre-treatment was observed. From these, 2.0 (1.0\u20133.0) were PMD\/month, and 7.0 (4.0\u201311.0) were non-PMD\/month. After treatment, the median PHD\/month was 2.0 (1.0\u20133.0) (corresponding to 16.67% of MHD) (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.085), and 8.0 (5.0\u201313.0) were non-PHD\/month (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001); from these, 1.0 (0.0\u20133.0) were PMD\/month (proportion difference,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.035) and 4.0 (2.0\u20137.0) were non-PMD (proportion difference,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). When analyzing grouped by treatment, only patients treated with anti-CGRP experienced a reduction in PMD. No statistically significant differences in clinical factors (aura, migraine diagnosis, contraceptive intake) between PHD\/non-PHD or PMD\/non-PMD, either pre- or post-treatment. A higher probability risk of headache and migraine during the perimenstrual window was observed independently of the treatment received (odds ratio = 1.637, 95% confidence interval = 1.356\u20131.984,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Three-month treatment with anti-CGRP mAbs or BTX-A effectively reduced non-PHD and non-PMD but had limited effect on PHD\/PMD because headache probability risk was higher during the perimenstrual window after treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251332519","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T14:47:05Z","timestamp":1744814825000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of anti-CGRP monoclonal antibodies and onabotulinumtoxinA in menstrually-related migraine: The unmet need of perimenstrual headache days"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7064-904X","authenticated-orcid":false,"given":"Rut","family":"Mas-de-les-Valls","sequence":"first","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8119-7489","authenticated-orcid":false,"given":"Laura","family":"G\u00f3mez-Dab\u00f3","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Headache Clinic, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-0267","authenticated-orcid":false,"given":"Edoardo","family":"Caronna","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Headache Clinic, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-2007","authenticated-orcid":false,"given":"Victor J","family":"Gallardo","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-9401","authenticated-orcid":false,"given":"Alicia","family":"Alpuente","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Headache Clinic, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-4134","authenticated-orcid":false,"given":"Marta","family":"Torres-Ferrus","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Headache Clinic, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-4702","authenticated-orcid":false,"given":"Patricia","family":"Pozo-Rosich","sequence":"additional","affiliation":[{"name":"Headache and Neurological Pain Research Group, Vall d\u2019Hebron Research Institute, Barcelona, Spain"},{"name":"Headache Clinic, Neurology Department, Hospital Universitari Vall d\u2019Hebron, Department of Medicine, Universitat Aut\u00f2noma de Barcelona, Barcelona, 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