{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:45:49Z","timestamp":1784634349699,"version":"3.55.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Lundbeck Foundation Professor Grant","award":["R310-2018\u20133711"],"award-info":[{"award-number":["R310-2018\u20133711"]}]},{"name":"Rigshospitalets Forskningspuljer","award":["E-23327-03"],"award-info":[{"award-number":["E-23327-03"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate whether early administration of sumatriptan prevents migraine induced by ATP-sensitive potassium (K\n                      <jats:sub>ATP<\/jats:sub>\n                      ) channel opener levcromakalim.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-centre, randomised, double-blind, placebo-controlled, two-way crossover study included adults with migraine without aura. Participants received a 20-minute intravenous infusion of levcromakalim on two separate occasions, followed immediately by a 10-minute intravenous infusion of either sumatriptan or placebo (isotonic saline) in a balanced allocation. The primary endpoint was the difference in the incidence of levcromakalim-induced migraine aftersumatriptan versus placebo over 12 hours. A secondary endpoint was the area under the curve (AUC) for headache intensity scores between experimental days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty of 24 participants completed the study. The incidence of migraine induced by levcromakalim was 75% following sumatriptan and 85% following placebo (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.69). The AUC for headache intensity scores showed no difference between sumatriptan and placebo days (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.12). Post-hoc analyses correcting for intensity at 40 minutes post-levcromakalim revealed a significantly lower AUC for headache intensity following sumatriptan compared with placebo (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Early sumatriptan treatment does not prevent migraine induced by K\n                      <jats:sub>ATP<\/jats:sub>\n                      channel opening, suggesting that K\n                      <jats:sub>ATP<\/jats:sub>\n                      -induced migraine occurs downstream of sumatriptan's site of action. However, sumatriptan reduces headache intensity, warranting further exploration of its modulatory effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251341464","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T02:53:13Z","timestamp":1751943193000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of sumatriptan on ATP-sensitive potassium channel opening in migraine: A randomised controlled trial"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0041-7389","authenticated-orcid":false,"given":"Zixuan Alice","family":"Zhuang","sequence":"first","affiliation":[{"name":"Danish Headache Centre, Copenhagen University Hospital \u2013 Rigshospitalet"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1118-9665","authenticated-orcid":false,"given":"Mohammad Al-Mahdi","family":"Al-Karagholi","sequence":"additional","affiliation":[{"name":"Danish Headache Centre, Copenhagen University Hospital \u2013 Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-727X","authenticated-orcid":false,"given":"H\u00e5kan","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Centre, Copenhagen University Hospital \u2013 Rigshospitalet"},{"name":"Translational Research Centre, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3662-5582","authenticated-orcid":false,"given":"Thien Phu","family":"Do","sequence":"additional","affiliation":[{"name":"Danish Headache Centre, Copenhagen University Hospital \u2013 Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-5804","authenticated-orcid":false,"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Danish Headache Centre, Copenhagen University Hospital \u2013 Rigshospitalet"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1915327"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30185-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32162-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-080107"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024221143773"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.03.008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413483374"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306147101"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420975395"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1996.1606412.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz199"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab136"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.13634"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241237247"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241248211"},{"key":"e_1_3_3_17_2","article-title":"CONSORT 2010 Statement: extension to randomised crossover trials","volume":"366","author":"Dwan K","year":"2019","unstructured":"Dwan K, Li T, Altman DG, et al. 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