{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:55:22Z","timestamp":1781657722538,"version":"3.54.5"},"reference-count":51,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R310-2018-3711"],"award-info":[{"award-number":["R310-2018-3711"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R403-2022-1352"],"award-info":[{"award-number":["R403-2022-1352"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cephalalgia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Persistent post-traumatic headache (PTH) is a prevalent and disabling neurological disorder, often attributed to mild traumatic brain injury and resembling migraine in clinical features. The underlying cortical morphometric changes and their relevance to persistent PTH remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross-sectional magnetic resonance imaging (MRI) investigation enrolled 103 adults with persistent PTH, 296 with migraine and 155 healthy controls (HC), to undergo structural MRI at 3T. Cortical surface area, thickness and volume were evaluated in FreeSurfer. The analyses applied cluster-determining thresholds of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and cluster-wise thresholds of\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, adjusted for age, sex and total intracranial volume.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants with persistent PTH exhibited larger surface area in the right anterior and posterior cingulate cortex (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>cluster<\/jats:sub>\n                      \u2009=\u20090.003), as well as the right superior parietal cortex\/postcentral gyrus, compared to HC (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>cluster<\/jats:sub>\n                      \u2009&lt;\u20090.035). No morphometric differences were observed between participants with persistent PTH and migraine (including subgroups: episodic, chronic, with aura without aura).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings reveal morphometric alterations in persistent PTH, specifically within pain processing regions of the mid-cingulate and somatosensory cortex. Similar changes have been reported in migraine, suggesting a shared neurobiological substrate. These enlargements might reflect adaptations to recurrent nociceptive stimuli that sustain persistent PTH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/03331024251362830","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T13:07:23Z","timestamp":1756127243000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Differences in cortical morphometry between persistent post-traumatic headache, migraine and healthy controls"],"prefix":"10.1177","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3384-3579","authenticated-orcid":false,"given":"Rune H\u00e4ckert","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Translational Research Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-3369","authenticated-orcid":false,"given":"Haidar Muhsen","family":"Al-Khazali","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Translational Research Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-5804","authenticated-orcid":false,"given":"Messoud","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Vashchenko","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-8743","authenticated-orcid":false,"given":"Rogelio","family":"Dominguez-Moreno","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Neurology and Psychiatry, Difficult-to-Treat Headache Clinic, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tolnai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-727X","authenticated-orcid":false,"given":"H\u00e5kan","family":"Ashina","sequence":"additional","affiliation":[{"name":"Department of Neurology, Danish Headache Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Translational Research Center, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00094-6"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0243-8"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.6.711"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2015-205429"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102420909865"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/03331024251331605"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.8.3.327"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-024-01341-4"},{"key":"e_1_3_2_11_2","article-title":"Thickening in the somatosensory cortex of patients with migraine","volume":"69","author":"DaSilva AFM","unstructured":"DaSilva AFM, Granziera C, Snyder J, et al. Thickening in the somatosensory cortex of patients with migraine. Neurology 69. Epub ahead of print 11 November 2007. DOI: https:\/\/doi.org\/10.1212\/01.WNL.0000291618.32247.2D.","journal-title":"Neurology"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412445622"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209305"},{"key":"e_1_3_2_14_2","article-title":"Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure","volume":"18","author":"Schwedt TJ","unstructured":"Schwedt TJ, Chong CD, Peplinski J, et al. Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure. J Headache Pain 18. Epub ahead of print 1 December 2017. DOI: https:\/\/doi.org\/10.1186\/S10194-017-0796-0.","journal-title":"J Headache Pain"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.13223"},{"key":"e_1_3_2_16_2","article-title":"Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain","volume":"21","author":"Niu X","unstructured":"Niu X, Bai L, Sun Y, et al. Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain. J Headache Pain 21. Epub ahead of print 1 December 2020. DOI: https:\/\/doi.org\/10.1186\/S10194-020-01201-7.","journal-title":"J Headache Pain"},{"key":"e_1_3_2_17_2","article-title":"Headache classification and automatic biomarker extraction from structural MRIs using deep learning","volume":"5","author":"Rahman Siddiquee MM","unstructured":"Rahman Siddiquee MM, Shah J, Chong C, et al. Headache classification and automatic biomarker extraction from structural MRIs using deep learning. Brain Commun 5. Epub ahead of print 2022. DOI: https:\/\/doi.org\/10.1093\/BRAINCOMMS\/FCAC311.","journal-title":"Brain Commun"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102421991819"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01604-2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad367"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25915"},{"key":"e_1_3_2_25_2","article-title":"Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache","volume":"43","author":"Al-Khazali HM","unstructured":"Al-Khazali HM, Christensen RH, Dodick DW, et al. Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache. Cephalalgia 43. Epub ahead of print 1 November 2023. DOI: https:\/\/doi.org\/10.1177\/03331024231210930.","journal-title":"Cephalalgia"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.12.072"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.10.021"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2014.00035"},{"key":"e_1_3_2_30_2","first-page":"485","article-title":"Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain","volume":"17","author":"Bliss TVP","year":"2016","unstructured":"Bliss TVP, Collingridge GL, Kaang BK, et al. Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain. Nature Reviews Neuroscience 2016 17:8 2016; 17: 485\u2013496.","journal-title":"Nature Reviews Neuroscience 2016 17:8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b8791a"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.06.010"},{"key":"e_1_3_2_33_2","article-title":"Automated anatomical labelling atlas 3","volume":"206","author":"Rolls ET","unstructured":"Rolls ET, Huang CC, Lin CP, et al. Automated anatomical labelling atlas 3. Neuroimage 206. Epub ahead of print 1 February 2020. DOI: https:\/\/doi.org\/10.1016\/J.NEUROIMAGE.2019.116189.","journal-title":"Neuroimage"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2994"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515083112"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac403"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2003.03034.x"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb01608.x"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu001"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2934-07.2008"},{"key":"e_1_3_2_41_2","first-page":"1591","article-title":"A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity","volume":"20","author":"Tan LL","year":"2017","unstructured":"Tan LL, Pelzer P, Heinl C, et al. A pathway from midcingulate cortex to posterior insula gates nociceptive hypersensitivity. Nature Neurosci 2017 20:11 2017; 20: 1591\u20131601.","journal-title":"Nature Neurosci 2017 20:11"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00561-6"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/8065"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0603-08.2008"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature02617"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-024-01351-2"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413499645"},{"key":"e_1_3_2_48_2","first-page":"3","article-title":"CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury","volume":"23","author":"Ashina H","unstructured":"Ashina H, Iljazi A, Al-Khazali HM, et al. CGRP-induced migraine-like headache in persistent post-traumatic headache attributed to mild traumatic brain injury. J Headache Pain 2022; 23: 135.","journal-title":"J Headache Pain"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-013-2692-x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23484"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3285-11.2011"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.05.033"}],"container-title":["Cephalalgia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024251362830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/03331024251362830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/03331024251362830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:47:02Z","timestamp":1777387622000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/03331024251362830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":51,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/03331024251362830"],"URL":"https:\/\/doi.org\/10.1177\/03331024251362830","relation":{},"ISSN":["0333-1024","1468-2982"],"issn-type":[{"value":"0333-1024","type":"print"},{"value":"1468-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"03331024251362830"}}